Giane 35 (Tablet)
Manufactured by: Renata Limited
Cyproterone Acetate + Ethinylestradiol Similar medicine
Giane 35 is indicated for
- Acne
- Contraception
- Hirsutism
- Prostatic carcinoma
- Libido
- Hot flushes
Precautions and warnings
People with prostate cancer, liver problems, diabetes, a history of depression, genetic issues with fat metabolism, or heart and blood vessel diseases should be careful with this treatment. During use, monitor liver function, adrenal gland function, cholesterol levels (LDL and HDL), and red blood cell count. For women: Stop the treatment if there is ongoing or repeat bleeding to rule out any serious underlying conditions. This medication may increase the risk of blood clots. It does not work for reducing sexual drive in men with long-term alcoholism. It might also affect your ability to drive or use machinery. Do not use during pregnancy or breastfeeding.
Side-effects
- Inhibits spermatogenesis
- reduces volume of ejaculate
- causes infertility
- produces abnormal spermatozoa
- gynecomastia
- enlargement of mammary glands; galactorrhoea
- benign nodules. Depressive mood changes. Alterations in hair pattern
- skin reactions. Fatigue
- lassitude
- breathlessness
- wt changes.
Drug Interactions
Some medicines, like ketoconazole, itraconazole, clotrimazole, and ritonavir, can slow down the breakdown of other drugs by blocking the enzyme CYP3A4. Others, like rifampicin and phenytoin, can speed up this process and lower the amount of certain drugs, such as cyproterone, in your body.
Medications that increase the activity of enzymes CYP1A2 and CYP3A4 (for example, aminoglutethimide, carbamazepine, phenobarbital, and rifampin) may make estradiol less effective.
When taken together, these drugs may increase the effects of hydrocortisone and prednisolone. They can also change how well dicoumarol (a blood thinner) works.
Potentially serious: Some antibiotics (like ampicillin, tetracycline, sulphonamides, and chloramphenicol) may cause unexpected bleeding between periods or make birth control pills less effective. They may also reduce how well blood pressure medicines or diabetes medications work.
Contraindications
Serious liver problems or blocked bile flow; Dubin-Johnson or Rotor syndrome; liver tumors; cancer or severe wasting illnesses; severe ongoing depression; advanced diabetes with blood vessel damage; sickle cell anemia; past blood clots; kidney problems. Young people.
Mode of actions
Cyproterone is a type of progestogen that also blocks the effects of male hormones (androgens). Oestradiol is the main estrogen hormone in women before menopause, while ethinylestradiol has similar effects to oestradiol. These hormones help develop and maintain the female reproductive system and secondary sexual traits, like breast development. They also stop certain hormones from being released by the anterior pituitary gland through negative feedback, and can cause blood vessels to widen, the body to hold onto more fluid, and increase protein production.
Dosage & Administration
Adult: PO Acne; Contraception; Hirsutism 2 mg/day (w/ ethinylestradiol) for 21 days of the menstrual cycle.
Palliative treatment for prostatic carcinoma Initial: 300 mg/day in 2-3 divided doses. Maintenance: 200-300 mg/day.
Control of libido 50 mg twice daily. Hot flushes 50mg/day, may increase to 150 mg/day in 3 divided doses if needed.
Pregnancy & Lactation
This medicine must not be used during pregnancy. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict two effective types of birth control starting one month before and during treatment and for three years after stopping this medicine. Discuss with your doctors if you are not sure which types of birth control are effective for you. You must need to take pregnancy tests regularly during your treatment with this medicine and for at least three years after taking this medicine. If it seems that you do become pregnant stop taking this medicine and call your doctor immediately. If you really become pregnant, miss a menstrual period, or have sex without using two forms of birth control. In some cases, your doctor can prescribe emergency contraception to prevent pregnancy. People on this medicine should not donate blood during the treatment and for three years afterward.
This medicine is also contraindicated breast milk. Breastfeeding is not recommended while using this medication and for three years afterward.
Pack Size & Price
1 x 21 's pack Price : ৳150.78
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Manufactured by: Renata Limited
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