Bizoran 5/40 5 mg + 40 mg (Tablet)
Manufactured by: Beximco Pharmaceuticals Ltd.
Amlodipine + Olmesartan Medoxomil Similar medicine
Bizoran 5/40 is indicated for
- 高血壓
Precautions and warnings
在懷孕中期和晚期服用影響腎素-血管緊張素系統的藥物可能會導致胎兒損傷和死亡。 一旦偵測到妊娠，應盡快停用奧美沙坦酯。 容量和/或鹽不足的患者可能會出現症狀性低血壓。 少尿、進行性氮質血症和急性腎衰竭都與這種情況有關（罕見）。 雙側或單側腎動脈狹窄的患者較容易出現嚴重低血壓和腎功能不全。 腎功能不全者應謹慎使用；應定期檢查血清肌酸酐和鉀水平。 如果您有嚴重腎功能損傷 (CrClandlt; 20 mL/min) 或嚴重肝功能損害 (CrClandlt; 20 mL/min)，請謹慎使用。 主動脈瓣或二尖瓣狹窄或阻塞性肥厚型心肌病變患者應謹慎。
血管張力素受體拮抗劑可能對原發性醛固酮增多症患者無效。
不建議哺乳。
Side-effects
- 頭暈、頭痛、腹痛、消化不良、腹瀉、胃腸炎、噁心、胸痛、支氣管炎、咳嗽、咽炎、鼻炎、關節炎、背痛、疲勞、流感樣症狀、低血壓、週邊水腫、血尿、泌尿道感染、高血鉀症、高三酸甘油脂血症、高尿酸血症、肝酵素升高、臉部水腫、血管性水腫、橫紋肌腫、血管性水腫、高尿酸血症、血管性水腫、臉部水腫、血管性水腫、橫紋肌酸血症。 潛在致命：急性腎衰竭。
Drug Interactions
與消耗兒茶酚胺的藥物一起使用時，存在低血壓和/或顯著心搏過緩的風險。 為避免高血壓反跳，可樂定應在停用β受體阻斷劑幾天後停用；如果用β受體阻斷劑取代可樂定，則應在停用可樂定幾天后才開始使用β受體阻斷劑。 與前列腺素合成酶抑制劑（如吲哚美辛）同時使用可能會減弱β受體阻斷劑的降血壓作用。 ACE 抑制劑、保鉀利尿劑、鉀鹽或鉀補充劑以及可能增加血清鉀的藥物都會增加高血鉀的風險（例如環孢素、依普利農）。 與其他抗高血壓藥物一起，它可以增強降低血壓的效果。 與非類固醇抗發炎藥物一起使用時，腎小球濾過可能會減少，導致急性腎衰竭。 鋰的毒性和血清濃度可能會增加。
ACE 抑制劑、保鉀利尿劑、鉀鹽或鉀補充劑以及可能增加血清鉀的藥物都會增加高血鉀的風險（例如環孢素、依普利農）。 與其他抗高血壓藥物一起，它可以增強降低血壓的效果。 與非類固醇抗發炎藥物一起使用時，腎小球濾過可能會減少，導致急性腎衰竭。 鋰的毒性和血清濃度可能會增加。
Contraindications
懷孕期間（妊娠中期和晚期）膽道阻塞。
Mode of actions
氨氯地平可放鬆週邊動脈和冠狀動脈的平滑肌。 在去極化過程中，它抑制Ca離子進入血管平滑肌和心臟的慢通道或選擇電壓敏感通道，導致冠狀血管舒張。 對於血管痙攣性心絞痛患者，它還可以改善心肌氧氣輸送。
奧美沙坦是一種選擇性和競爭性血管緊張素 II 1 型 (AT1) 受體拮抗劑，可防止血管緊張素 II 充當血管收縮劑並分泌醛固酮。 奧美沙坦可以放鬆動脈，降低血壓，從而增加心臟的血液供應和氧氣。
Dosage & Administration
成人：初始：10-20 mg，每日一次。 抗高血壓作用在治療開始後 2 週內基本顯現。 如有需要，劑量可增加至 40 mg，每日一次。 對於血管內容量可能不足的患者（例如同時接受利尿劑的患者，尤其是腎功能不全的患者），可以考慮降低起始劑量。
兒童：6至16歲：20-35公斤：10毫克，每日一次，可增加至最大劑量20毫克，每日一次。 >35 kg：20 mg 每日一次，可增加至最高 40 mg 每日一次。
老年人：可以考慮每天 5-10 毫克的較低起始劑量。
Pregnancy & Lactation
儘管動物生殖研究顯示對胎兒有不良影響，並且在孕婦中沒有充分且良好對照的研究，但在懷孕期間，儘管存在潛在風險，但在確實需要時可以使用該藥物。
另一項研究表明，懷孕期間不允許使用這種藥物。 如果您懷孕了，請勿使用它。 它可以透過皮膚和肺部吸收，從而損害未出生孩子的器官並導致先天性殘疾。 治療期間及停藥後六個月內嚴格有效的節育。 如果您確實懷孕了，請停止服用此藥並立即與您的醫生討論。
沒有關於這種藥物是否會進入母乳的具體資訊。 考慮到兒童可能存在的風險，不建議在使用該藥物時進行母乳喂養，並且至少在最後一次用藥後兩週進行母乳喂養。 哺乳前請先諮詢您的醫生。
Pack Size & Price
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