A Mycin (Lotion)
Manufactured by: Aristopharma Limited
Erythromycin solution Similar medicine
A Mycin is indicated for
- Acne
Precautions and warnings
There is a higher risk of cholestatic hepatitis if treatment lasts more than 10 days or in patients who have previously used erythromycin. Use caution in people with a history of liver problems, heart rhythm disorders, prolonged QT interval, or those who are breastfeeding. Monitor liver function regularly. Do not use the estolate form in patients with liver problems. Be careful with the lactobionate form in patients who have severe kidney problems. This medication can also make muscle weakness worse in people with myasthenia gravis.
Side-effects
- Rash
- urticaria; nausea
- vomiting
- GI discomfort; ototoxicity; central neurotoxicity; agranulocytosis; arrhythmias; pancreatitis. Potentially Fatal: Hepatotoxicity
- cholestatic jaundice; raised serum transaminases; eosinophilia.
Drug Interactions
Using erythromycin with other medicines can cause serious side effects:
- **Muscle breakdown (rhabdomyolysis)**, with or without kidney problems, can occur when taken with statins like simvastatin.
- **Colchicine toxicity** risk is higher.
- **More sedation** may happen if taken with benzodiazepines such as alprazolam or midazolam.
- The amount of erythromycin in your body may **increase with cimetidine** and **decrease with theophylline**.
- When combined with calcium channel blockers like verapamil, amlodipine, or diltiazem, it can cause **low blood pressure, irregular heartbeats, and lactic acidosis**.
- **Sildenafil (Viagra)** levels can increase.
- Adverse effects may be increased or last longer if taken with drugs like ciclosporin, carbamazepine, tacrolimus, alfentanil, disopyramide, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine, or bromocriptine.
- There is a higher risk of **digoxin toxicity**.
- It can also **increase bleeding** with oral blood thinners (anticoagulants).
**Life-threatening risks include**:
- Dangerous heart rhythm problems (like QT prolongation, irregular heartbeats, ventricular tachycardia or fibrillation, and torsades de pointes) with cisapride, pimozide, astemizole, or terfenadine.
- **Severe ergot toxicity** if used with ergotamine or dihydroergotamine.
Contraindications
Hypersensitivity; porphyria; hepatic impairment; pregnancy.
Mode of actions
Erythromycin stops bacteria from making proteins by permanently attaching to the 50S part of their ribosomes. This blocks certain steps needed for the bacteria to grow, so their growth slows down or stops.
Dosage & Administration
As cream/solution: Apply onto affected areas 1-2 times daily.
Discontinue treatment if condition worsens or if there is no improvement after 6-8 wk of continuous usage.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.
Discuss with your doctors and tell them feedback about this medicine.
There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.
Pack Size & Price
25ml bot Price : ৳120
Similar medicine
Manufactured by: Sanofi Aventis (BD) Ltd.
Manufactured by: Aristopharma Limited
Manufactured by: Square Pharmaceuticals Ltd.
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