Penicillin G Sodium 10 LacIU (Injection)
Manufactured by: Renata Limited
Benzyl Penicillin Similar medicine
Penicillin G Sodium is indicated for
- Meningitis
- Anthrax
- Community-acquired pneumonia
- Bacterial endocarditis
- Septicemia
- Diphtheria
- Syphilis
- Cellulitis
- Infective endocarditis
- Gonorrhea
- Aspiration pneumonia
- Lung abscess
- Septic Arthritis
- Gangrene
- Meningococcal meningitis
- Pneumococcal meningitis
- Botulism
Precautions and warnings
In patients with impaired renal function (risk of neurotoxicity) or heart failure, very high doses are used. Skin sensitization may occur if you come into contact with it. Keep an eye on your potassium levels in the blood, as well as your renal and hematological health. Avoid the intrathecal route for lactation if you have spirochete infections, especially syphilis, or if you have a long-term infection with penicillin-resistant organisms.
Side-effects
- Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Potentially Fatal: Anaphylaxis.
Drug Interactions
Increases and prolongs serum penicillin levels with probenecid.
Tetracycline may counteract penicillin's bactericidal effect.
Contraindications
Hypersensitivity to penicillins.
Mode of actions
Gram-positive bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes, and actinomycetes are all susceptible to benzylpenicillin. It inhibits bacterial cell wall synthesis by binding and inactivating transpeptidases on the inner surface of the bacterial cell membrane, preventing the final cross-linking stage of peptidoglycan biosynthesis. Penicillinase and other lactamases are inhibitors.
Dosage & Administration
Adult: IV Bacterial endocarditis W/ aminoglycoside: 1.2 g 4 hrly. Intrapartum prophylaxis against group B streptococcal infection Initial: 3 g, then 1.5 g 4 hrly until delivery.
Meningococcal meningitis; Pneumococcal meningitis 2.4 g 4 hrly. Up to 18 g/day in meningococcal meningitis.
IV/IM Susceptible infections 0.6-4.8 g/day in divided doses.
Infant & Children: Bacterial Infection
Moderate Infection: 25,000-50,000 units/kg/day IV/IM divided 6hourly
Severe Infection: 250,000-400,000 units/kg/day IV/IM divided 4-6 hourly
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.
Discuss with your doctors and tell them feedback about this medicine.
There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.
Pack Size & Price
1 vial Price : ৳9.21
Similar medicine
Manufactured by: Opsonin Pharma Limited
Manufactured by: Renata Limited
Manufactured by: Renata Limited
Manufactured by: Opsonin Pharma Limited
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