Penicillin G Sodium 10 LacIU (Injection)
Manufactured by: Renata Limited
Benzyl Penicillin Similar medicine
Penicillin G Sodium is indicated for
- Meningitis
- Milzbrand
- ambulant erworbene Lungenentzündung
- bakterielle Endokarditis
- Septikämie
- Diphtherie
- Syphilis
- Zellulitis
- infektiöse Endokarditis
- Gonorrhoe
- Aspirationspneumonie
- Lungenabszess
- septische Arthritis
- Gangrän
- Meningokokken-Meningitis
- Pneumokokken-Meningitis
- Botulismus
Precautions and warnings
Bei Patienten mit eingeschränkter Nierenfunktion (Gefahr einer Neurotoxizität) oder Herzinsuffizienz werden sehr hohe Dosen angewendet. Bei Kontakt kann es zu einer Hautsensibilisierung kommen. Behalten Sie Ihren Kaliumspiegel im Blut sowie Ihre Nieren- und hämatologische Gesundheit im Auge. Vermeiden Sie den intrathekalen Weg während der Stillzeit, wenn Sie an Spirochäteninfektionen, insbesondere Syphilis, leiden oder wenn Sie eine langfristige Infektion mit Penicillin-resistenten Organismen haben.
Side-effects
- Überempfindlichkeitsreaktionen einschließlich Utikaria; Fieber; Gelenkschmerzen; Hautausschläge; Angioödem; serumkrankheitsähnliche Reaktionen; hämolytische Anämie; interstitielle Nephritis; Neutropenie; Thrombozytopenie; ZNS-Toxizität einschließlich Krämpfen; Durchfall; Antibiotika-assoziierte Kolitis. Potenziell tödlich: Anaphylaxie.
Drug Interactions
Erhöht und verlängert den Penicillinspiegel im Serum mit Probenecid.
Tetracyclin kann der bakteriziden Wirkung von Penicillin entgegenwirken.
Contraindications
Überempfindlichkeit gegen Penicilline.
Mode of actions
Grampositive Bakterien, gramnegative Kokken, einige andere gramnegative Bakterien, Spirochäten und Actinomyceten sind alle anfällig für Benzylpenicillin. Es hemmt die bakterielle Zellwandsynthese, indem es Transpeptidasen auf der Innenfläche der bakteriellen Zellmembran bindet und inaktiviert und so die letzte Vernetzungsstufe der Peptidoglycan-Biosynthese verhindert. Penicillinase und andere Laktamasen sind Inhibitoren.
Dosage & Administration
Erwachsene: IV Bakterielle Endokarditis mit Aminoglykosid: 1,2 g 4 Stunden. Intrapartale Prophylaxe gegen Infektionen mit Streptokokken der Gruppe B. Anfänglich: 3 g, dann 1,5 g alle 4 Stunden bis zur Entbindung.
Meningokokken-Meningitis; Pneumokokken-Meningitis 2,4 g 4 Stunden. Bis zu 18 g/Tag bei Meningokokken-Meningitis.
IV/IM Anfällige Infektionen 0,6–4,8 g/Tag in geteilten Dosen.
Säuglinge und Kinder: Bakterielle Infektion
Mäßige Infektion: 25.000–50.000 Einheiten/kg/Tag IV/IM, aufgeteilt auf 6 Stunden
Schwere Infektion: 250.000–400.000 Einheiten/kg/Tag IV/IM, aufgeteilt auf 4–6 Stunden
Pregnancy & Lactation
Obwohl Reproduktionsstudien an Tieren eine schädliche Wirkung gezeigt haben, konnte das Risiko für den Fötus manchmal sogar nicht nachgewiesen werden, und es gibt keine ausreichenden und gut kontrollierten Studien bei schwangeren Frauen. Während der Schwangerschaft kann dieses Arzneimittel jedoch nur dann angewendet werden, wenn dies unbedingt erforderlich ist.
Besprechen Sie dies mit Ihren Ärzten und teilen Sie ihnen Feedback zu diesem Arzneimittel mit.
Es liegen keine spezifischen Informationen darüber vor, ob dieses Arzneimittel über die Muttermilch auf das Baby übertragen wird. Besprechen Sie dies mit Ihrem Arzt, bevor Sie stillen.
Pack Size & Price
1 vial Price : ৳9.21
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Manufactured by: Opsonin Pharma Limited
Manufactured by: Renata Limited
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