Oradexon 0.5mg (Tablet)
Manufactured by: Nuvista Pharma Ltd
Dexamethasone Similar medicine
Oradexon is indicated for
- Shock
- Bronchial asthma
- Status asthmaticus
- Rheumatoid arthritis
- Gout
- Severe allergies
- Skin diseases
- Hyperpyrexia
- Bacteraemia
- Toxaemia
- Acute adrenocortical insufficiency
- Cortisosteroid-responsive dermatoses
- Eczema
- Urticaria
- Cerebral oedema
- other indications where glucocorticoid therapy is required.
Precautions and warnings
Dexamethasone should be used carefully in people who have congestive heart failure, high blood pressure, diabetes, epilepsy, glaucoma, infections, chronic kidney failure, or high levels of waste in the blood (uraemia), as well as in older adults.
Side-effects
- Hypersensitivity including anaphylaxis
- allergic skin reactions has been reported. The incidence of predictable undesirable effects of glucocoticoids correlates with the dosage timing of administration
- duration of treatment. Patients on prolonged Dexamethasone therapy are at risk of collapse
- possibly death if their daily dose is not increased at times of severe physical stress e.g. injury
- surgery or infections. The somatic manifestations include growth retardation in children
- osteoporosis
- aseptic bone necrosis
- peptic ulceration
- ocular hypertension
- subcapsular cataract
- pancreatic disturbances
- myopathy. Other Cushing-like features characteristic of glucocorticoid excess includes truncal obesity
- moon-face
- oedema
- delayed wound healing
- glaucoma
- various psychiatric syndromes. These are all generally reversible with discontinuation of Dexamethasone treatment.
Drug Interactions
Using this medicine with other drugs that lower potassium, like amphotericin B and loop diuretics, can increase the risk of low potassium levels (hypokalaemia). It can also make medicines like isoniazid, salicylates, vaccines, and toxoids work less well. When taken together with dexamethasone or cyclosporin, the effects of these drugs may be stronger. Taking this medicine with aspirin or alcohol can increase the risk of stomach and digestive side effects.
Serious Warning: This medicine may be less effective if taken with ephedrine, cholestyramine, phenytoin, phenobarbital, or rifampicin. This combination can be dangerous.
Contraindications
Ocular herpes simplex is a condition where corticosteroid therapy should never be used. There are also some situations where using corticosteroids should be done with caution. These include having a stomach ulcer, current or recent infections, weak bones (osteoporosis), pregnancy, diabetes, kidney problems, high blood pressure, a history of mental illness, being about to get a vaccine, or being allergic to dexamethasone.
Mode of actions
Dexamethasone is a man-made steroid that reduces inflammation by stopping white blood cells from moving to the affected area and by helping blood vessels return to normal. It also lowers the body’s usual immune response.
Dosage & Administration
Usual oral dosage range is 0.5-10 mg daily.
Dexamethasone can be given parenterally at doses of 0.5-20 mg daily, either as a single IV/IM injection or by IV infusion.
Child: 200-500 mcg/kg daily. Cerebral oedema: 10 mg IV initially, then 4 mg IM every 6 hours as required for 2-10 days. Large IV doses should be given slowly to reduce the possibility of cardiovascular collapse.
Shock: By intravenous or intramascular injection or infusion 2-6 mg/kg, repeated if necessary after 2-6 hours.
The total daily intake of Dexamethasone, even in acute conditions should not exceed 80 mg except in certain very special circumstances.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
500's pack Price : ৳575
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