Oradexon 0.5mg (Tablet)
Manufactured by: Nuvista Pharma Ltd
Dexamethasone Similar medicine
Oradexon is indicated for
- Syok
- Asma bronkial
- Status asmatikus
- Artritis reumatoid
- Asam Urat
- Alergi berat
- Penyakit kulit
- Hiperpireksia
- Bakteremia
- Toksemia
- Insufisiensi adrenokortikal akut
- Dermatosis yang responsif terhadap kortisosteroid
- Eksim
- Urtikaria
- Edema serebral
- indikasi lain yang memerlukan terapi glukokortikoid.
Precautions and warnings
Deksametason harus digunakan dengan hati-hati pada orang yang menderita gagal jantung kongestif, tekanan darah tinggi, diabetes, epilepsi, glaukoma, infeksi, gagal ginjal kronis, atau tingginya kadar limbah dalam darah (uremia), serta pada orang dewasa yang lebih tua.
Side-effects
- Hipersensitivitas termasuk anafilaksis dan reaksi alergi pada kulit telah dilaporkan. Insiden efek glukotikoid yang tidak diinginkan dapat diprediksi berkorelasi dengan waktu pemberian dosis dan durasi pengobatan. Pasien yang menjalani terapi Dexamethasone jangka panjang berisiko kolaps dan kemungkinan kematian jika dosis harian mereka tidak ditingkatkan pada saat stres fisik yang parah
- misalnya. cedera
- pembedahan
- atau infeksi. Manifestasi somatik meliputi keterbelakangan pertumbuhan pada anak-anak
- osteoporosis dan nekrosis tulang aseptik
- tukak lambung
- hipertensi okular
- katarak subkapsular
- gangguan pankreas dan miopati. Ciri-ciri mirip Cushing lainnya yang merupakan karakteristik kelebihan glukokortikoid meliputi obesitas batang tubuh
- wajah bulan
- edema
- penyembuhan luka yang tertunda
- glaukoma
- dan berbagai sindrom kejiwaan. Ini semua umumnya dapat disembuhkan dengan penghentian pengobatan Dexamethasone.
Drug Interactions
Menggunakan obat ini dengan obat lain yang menurunkan kalium, seperti amfoterisin B dan diuretik loop, dapat meningkatkan risiko kadar kalium rendah (hipokalemia). Hal ini juga dapat membuat obat-obatan seperti isoniazid, salisilat, vaksin, dan toksoid bekerja kurang baik. Jika dikonsumsi bersamaan dengan deksametason atau siklosporin, efek obat ini mungkin lebih kuat. Mengonsumsi obat ini dengan aspirin atau alkohol dapat meningkatkan risiko efek samping lambung dan pencernaan.
Peringatan Serius: Obat ini mungkin kurang efektif jika dikonsumsi bersama efedrin, kolestiramin, fenitoin, fenobarbital, atau rifampisin. Kombinasi ini bisa berbahaya.
Contraindications
Herpes simpleks okular adalah suatu kondisi di mana terapi kortikosteroid tidak boleh digunakan. Ada juga beberapa situasi di mana penggunaan kortikosteroid harus dilakukan dengan hati-hati. Ini termasuk menderita sakit maag, infeksi yang sedang atau baru terjadi, tulang lemah (osteoporosis), kehamilan, diabetes, masalah ginjal, tekanan darah tinggi, riwayat penyakit mental, akan mendapatkan vaksin, atau alergi terhadap deksametason.
Mode of actions
Deksametason adalah steroid buatan yang mengurangi peradangan dengan menghentikan pergerakan sel darah putih ke area yang terkena dan membantu pembuluh darah kembali normal. Ini juga menurunkan respons imun tubuh yang biasa.
Dosage & Administration
Kisaran dosis oral biasa adalah 0,5-10 mg setiap hari.
Deksametason dapat diberikan secara parenteral dengan dosis 0,5-20 mg setiap hari, baik sebagai suntikan IV/IM tunggal atau infus IV.
Anak-anak: 200-500 mcg/kg setiap hari. Edema serebral: 10 mg IV pada awalnya, kemudian 4 mg IM setiap 6 jam sesuai kebutuhan selama 2-10 hari. Dosis IV yang besar harus diberikan secara perlahan untuk mengurangi kemungkinan kolaps kardiovaskular.
Syok: Melalui suntikan atau infus intravena atau intramaskuler 2-6 mg/kg, diulang jika perlu setelah 2-6 jam.
Total asupan harian Dexamethasone, bahkan dalam kondisi akut tidak boleh melebihi 80 mg kecuali dalam keadaan tertentu yang sangat khusus.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Ibu dengan bayi baru lahir yang telah menggunakan obat ini selama 3 bulan terakhir kehamilan mungkin jarang mengalami gejala termasuk mengantuk, otot kaku atau gemetar, kesulitan makan atau bernapas, dan menangis terus-menerus. Jika Anda melihat gejala-gejala ini pada bayi Anda terutama pada bulan pertama, segera beri tahu dokter.
Obat ini masuk ke dalam ASI. Bicaralah dengan dokter Anda sebelum menyusui.
Pack Size & Price
500's pack Price : ৳575
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