Rasilez 300mg (Tablet)
Manufactured by: Novartis Farma SpA, Italy
Aliskiren Similar medicine
Rasilez is indicated for
- Hypertension
Precautions and warnings
Severe CHF, sodium depletion, or volume depletion. If diarrhea is severe and persistent, stop taking it. Lactation. Parameters to be monitored Monitor serum potassium levels and renal function on a regular basis.
Side-effects
- Diarrhoea
- dyspepsia
- GERD
- abdominal pain
- hypotension
- headache
- fatigue
- dizziness
- back pain
- cough
- rashes
- hyperuricaemia
- gout
- renal calculi
- hyperkalaemia
- decreases in Hb levels (dose-related)
- angioedema
- seizures. Potentially Fatal: Anaphylactic reactions.
Drug Interactions
Along with other antihypertensives, there is an increased risk of hypotension. ACE inhibitors, angiotensin II receptor antagonists, and nonsteroidal anti-inflammatory drugs all increase the risk of acute renal failure. With NSAIDs, the antihypertensive impact may be diminished. Atorvastatin, itraconazole, ketoconazole, and verapamil all increased serum levels. Furosemide and aliskiren concentrations both dropped significantly. With potassium-sparing diuretics, potassium supplements, or any other agent that may raise serum potassium levels, there is an increased risk of hyperkalemia.
With ACE inhibitors or angiotensin II receptor antagonists, there is a higher risk of renal impairment, hypotension, and hyperkalemia. Markedly increased plasma concentration w/ ciclosporin, itraconazole, and quinidine.
Contraindications
Angioedema history; significant renal impairment In patients with diabetes and renal impairment (GFR), concomitant use of ACE inhibitors or angiotensin II receptor antagonists is recommended.
Mode of actions
Aliskiren is a non-peptide, orally active, powerful, and specific direct renin inhibitor used to treat HTN. It blocks the conversion of angiotensinogen into angiotensin I and thus the subsequent synthesis of angiotensin II and aldosterone by blocking the enzyme renin. Treatment with aliskiren reduces plasma renin activity and concentrations of angiotensin I, angiotensin II, and aldosterone, unlike ACE inhibitors and angiotensin II receptor antagonists, which promote a compensatory surge in plasma renin activity.
Dosage & Administration
Oral
Essential hypertension
Adult: >18 yr 150 mg once daily, increased to 300 mg once daily if needed.
Elderly: No dosage adjustment needed.
Hepatic impairment: No dosage adjustment needed.
Pregnancy & Lactation
This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.
There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.
Pack Size & Price
7's pack Price : ৳437.5
Similar medicine
Manufactured by: Novartis Farma SpA, Italy
Manufactured by: Novartis Farma SpA, Italy
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There are few similar medicines of Rasilez are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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