Rasilez 300mg (Tablet)
Manufactured by: Novartis Farma SpA, Italy
Aliskiren Similar medicine
Rasilez is indicated for
- Hipertensi
Precautions and warnings
CHF berat, deplesi natrium, atau deplesi volume. Jika diare parah dan terus-menerus, hentikan penggunaan obat tersebut. Laktasi. Parameter yang harus dipantau Pantau kadar kalium serum dan fungsi ginjal secara teratur.
Side-effects
- Diare
- pencernaan yg terganggu
- GERD
- sakit perut
- hipotensi
- sakit kepala
- kelelahan
- pusing
- sakit punggung
- batuk
- ruam
- hiperurisemia
- asam urat
- batu ginjal
- hiperkalemia
- penurunan kadar Hb (terkait dosis)
- angioedema dan kejang. Berpotensi Fatal: Reaksi anafilaksis.
Drug Interactions
Seiring dengan obat antihipertensi lainnya, terdapat peningkatan risiko hipotensi. Penghambat ACE, antagonis reseptor angiotensin II, dan obat antiinflamasi nonsteroid semuanya meningkatkan risiko gagal ginjal akut. Dengan NSAID, dampak antihipertensi dapat dikurangi. Atorvastatin, itraconazole, ketoconazole, dan verapamil semuanya meningkatkan kadar serum. Konsentrasi furosemide dan aliskiren keduanya turun secara signifikan. Dengan diuretik hemat kalium, suplemen kalium, atau obat lain yang dapat meningkatkan kadar kalium serum, terdapat peningkatan risiko hiperkalemia.
Dengan ACE inhibitor atau antagonis reseptor angiotensin II, terdapat risiko lebih tinggi terjadinya gangguan ginjal, hipotensi, dan hiperkalemia. Peningkatan nyata konsentrasi plasma jika diberikan bersamaan dengan siklosporin, itrakonazol, dan kuinidin.
Contraindications
riwayat angioedema; gangguan ginjal yang signifikan Pada pasien dengan diabetes dan gangguan ginjal (GFR), dianjurkan penggunaan inhibitor ACE atau antagonis reseptor angiotensin II secara bersamaan.
Mode of actions
Aliskiren adalah penghambat renin langsung non-peptida, aktif secara oral, kuat, dan spesifik yang digunakan untuk mengobati HTN. Ini memblokir konversi angiotensinogen menjadi angiotensin I dan dengan demikian sintesis angiotensin II dan aldosteron selanjutnya dengan memblokir enzim renin. Pengobatan dengan aliskiren mengurangi aktivitas renin plasma dan konsentrasi angiotensin I, angiotensin II, dan aldosteron, tidak seperti inhibitor ACE dan antagonis reseptor angiotensin II, yang mendorong peningkatan kompensasi aktivitas renin plasma.
Dosage & Administration
Lisan
Hipertensi esensial
Dewasa: >18 tahun 150 mg 1 kali sehari, ditingkatkan menjadi 300 mg 1 kali sehari jika diperlukan.
Lansia: Tidak diperlukan penyesuaian dosis.
Gangguan hati: Tidak diperlukan penyesuaian dosis.
Pregnancy & Lactation
Obat ini tidak diperbolehkan selama kehamilan. Jangan gunakan jika Anda sedang hamil. Dapat diserap melalui kulit dan paru-paru sehingga dapat merusak organ tubuh anak Anda yang belum lahir dan menyebabkan cacat bawaan. Alat kontrasepsi yang efektif dan ketat selama pengobatan dan selama enam bulan setelah menghentikan obat ini. Jika Anda hamil, hentikan penggunaan obat ini dan segera diskusikan dengan dokter Anda.
Belum ada informasi spesifik apakah obat ini masuk ke dalam ASI atau tidak. Mengingat kemungkinan risiko pada anak-anak, menyusui saat menggunakan obat ini tidak dianjurkan dan setidaknya dua minggu setelah dosis terakhir. Konsultasikan dengan dokter Anda sebelum menyusui.
Pack Size & Price
7's pack Price : ৳437.5
Similar medicine
Manufactured by: Novartis Farma SpA, Italy
Manufactured by: Novartis Farma SpA, Italy
Click here to see more similar medicines
There are few similar medicines of Rasilez are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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