Combipen 4 LAC 300k+100k units per Vial (Injection)
Manufactured by: Acme Laboratories Ltd.
Benzyl Penicillin + Procaine Penicillin Similar medicine
Combipen 4 LAC is indicated for
- Méningite
- péritonite
- charbon
- urétrite non gonococcique
- diphtérie
- syphilis
- infections causées par Staphylococcus (souches sensibles)
- streptocoque
- gonorrhée de type Pneumococcus
- endocardite bactérienne subaiguë
- voies respiratoires supérieures
- érysipèle
- infections de la peau et des tissus mous
- pneumonie et otite moyenne modérément sévères
- empyème
- Bactériémie
- péricardite
- arthrite
Precautions and warnings
La pénicilline doit être prise avec prudence chez les personnes ayant des antécédents d'allergies graves ou d'asthme.
L'administration intraveineuse ou intra-artérielle, ainsi que les injections dans ou à proximité des principaux nerfs périphériques ou artères sanguines, doivent être évitées car elles peuvent provoquer des lésions neurovasculaires.
Side-effects
- Comme avec les autres pénicillines
- des réactions indésirables liées aux phénomènes de sensibilité sont susceptibles de se produire
- en particulier chez les personnes ayant déjà démontré une hypersensibilité aux pénicillines ou chez celles ayant des antécédents d'allergie
- d'asthme
- de rhume des foins ou d'urticaire. Les effets suivants ont été rapportés avec la pénicilline G parentérale : Général : réactions d'hypersensibilité incluant les suivantes : éruptions cutanées (dermatite maculopapuleuse à exfoliative)
- urticaire
- œdème laryngé
- fièvre
- éosinophilie ; d'autres réactions de type maladie sérique (y compris frissons
- fièvre
- œdème
- arthralgie et prostration) ; et l'anaphylaxie
- y compris le choc et la mort. Gastro-intestinal : Colite pseudomembraneuse. L’apparition de symptômes de colite pseudomembraneuse peut survenir pendant ou après un traitement antibactérien.
Drug Interactions
Augmente et prolonge les taux sériques de pénicilline avec le probénécide.
La tétracycline peut contrecarrer l'effet bactéricide de la pénicilline.
Contraindications
Toute réaction d’hypersensibilité à la pénicilline ou à la procaïne dans le passé constitue une contre-indication.
Mode of actions
Les bactéries à Gram positif, les coques à Gram négatif, certaines autres bactéries à Gram négatif, les spirochètes et les actinomycètes sont tous sensibles à la benzylpénicilline. Il inhibe la synthèse de la paroi cellulaire bactérienne en liant et en inactivant les transpeptidases sur la surface interne de la membrane cellulaire bactérienne, empêchant ainsi l'étape finale de réticulation de la biosynthèse du peptidoglycane. Penicillinase and other?-lactamases are inhibitors.
Interfère avec la synthèse des mucopeptides dans la paroi cellulaire lors de la multiplication active, entraînant une action bactéricide contre les bactéries sensibles.
Dosage & Administration
Infections streptococciques Groupe A - Infections des voies respiratoires supérieures, infections de la peau et des tissus mous, scarlatine et érysipèle.
Les doses suivantes sont recommandées :
Adultes et patients pédiatriques de plus de 60 lb. en poids : 2 400 000 unités.
Patients pédiatriques de 30 à 60 lbs : 900 000 unités à 1 200 000 unités.
Patients pédiatriques de moins de 30 livres : 600 000 unités.
REMARQUE : Le traitement avec la posologie recommandée est généralement administré en une seule séance en utilisant plusieurs sites IM lorsque cela est indiqué. Un schéma posologique alternatif peut être utilisé, donnant la moitié (1/2) de la dose totale le jour 1 et la moitié (1/2) le jour 3.
Infections à pneumocoque (sauf méningite à pneumocoque)
600 000 unités chez les patients pédiatriques et 1 200 000 unités chez les adultes, à répéter tous les 2 ou 3 jours jusqu'à ce que la température redevienne normale pendant 48 heures. D'autres formes de pénicilline peuvent être nécessaires dans les cas graves.
Pregnancy & Lactation
Bien que les études sur la reproduction animale aient montré un effet indésirable, même parfois sans pouvoir démontrer le risque pour le fœtus et qu'il n'existe pas d'études adéquates et bien contrôlées chez la femme enceinte, ce médicament peut être utilisé pendant la grossesse juste en cas de nécessité absolue.
Discutez avec vos médecins et faites-leur part de vos commentaires sur ce médicament.
Il n'existe aucune information spécifique indiquant si ce médicament est transmis au bébé par le lait maternel. Discutez-en avec votre médecin avant d'allaiter.
Pack Size & Price
5 vials pack Price : ৳70.25
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