Pronapen 8 LAC (Injection)
Manufactured by: Renata Limited
Benzyl Penicillin + Procaine Penicillin Similar medicine
Pronapen 8 LAC is indicated for
- Meningitis
- Peritonitis
- Anthrax
- Non-gonococcal urethritis
- Diphtheria
- Syphilis
- Infections caused by Staphylococcus (susceptible strains)
- Streptococcus
- Pneumococcus species gonorrhoea
- Subacute bacterial endocarditis
- Upper respiratory tract
- Erysipelas
- Skin
- soft tissue infections
- Moderately severe pneumonia
- otitis media
- Empyema
- Bacteremia
- Pericarditis
- Arthritis
Precautions and warnings
Penicillin should be taken with caution in people who have a history of severe allergies or asthma.
Intravenous or intraarterial delivery, as well as injections into or near major peripheral nerves or blood arteries, should be avoided because they can cause neurovascular injury.
Side-effects
- As with other penicillins
- untoward reactions of the sensitivity phenomena are likely to occur
- particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with a history of allergy
- asthma
- hay fever
- or urticaria. The following have been reported with parenteral penicillin G: General: Hypersensitivity reactions including the following: skin eruptions (maculopapular to exfoliative dermatitis)
- urticaria
- laryngeal edema
- fever
- eosinophilia; other serum sickness-like reactions (including chills
- fever
- edema
- arthralgia
- and prostration);
- anaphylaxis including shock
- death. Gastrointestinal: Pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment.
Drug Interactions
Increases and prolongs serum penicillin levels with probenecid.
Tetracycline may counteract penicillin's bactericidal effect.
Contraindications
Any penicillin or procaine hypersensitive reaction in the past is a contraindication.
Mode of actions
Gram-positive bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes, and actinomycetes are all susceptible to benzylpenicillin. It inhibits bacterial cell wall synthesis by binding and inactivating transpeptidases on the inner surface of the bacterial cell membrane, preventing the final cross-linking stage of peptidoglycan biosynthesis. Penicillinase and other?-lactamases are inhibitors.
Interferes with the synthesis of mucopeptides in the cell wall during active multiplication, resulting in bactericidal action against sensitive bacteria.
Dosage & Administration
Streptococcal Infections Group A-Infections of the upper-respiratory tract, skin and soft-tissue infections, scarlet fever, and erysipelas.
The following doses are recommended:
Adults and pediatric patients over 60 lbs. in weight: 2,400,000 units.
Pediatric patients from 30 to 60 lbs.: 900,000 units to 1,200,000 units.
Pediatric patients under 30 lbs.: 600,000 units.
NOTE: Treatment with the recommended dosage is usually given at a single session using multiple IM sites when indicated. An alternative dosage schedule may be used, giving one-half (1/2) the total dose on day 1 and one-half (1/2) on day 3.
Pneumococcal Infections (except pneumococcal meningitis)
600,000 units in pediatric patients and 1,200,000 units in adults, repeated every 2 or 3 days until the temperature is normal for 48 hours. Other forms of penicillin may be necessary for severe cases.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.
Discuss with your doctors and tell them feedback about this medicine.
There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.
Pack Size & Price
1 vial pack Price : ৳9.1
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