Pronapen 8 LAC (Injection)
Manufactured by: Renata Limited
Benzyl Penicillin + Procaine Penicillin Similar medicine
Pronapen 8 LAC is indicated for
- Meningitis
- Peritonitis
- Antraks
- Uretritis non-gonokokus
- Difteri
- Sifilis
- Infeksi yang disebabkan oleh Staphylococcus (strain yang rentan)
- Streptococcus
- Pneumococcus spesies gonorrhoea
- Endokarditis bakterial subakut
- Saluran pernafasan bagian atas
- Erisipelas
- Infeksi kulit dan jaringan lunak
- Pneumonia dan otitis media sedang
- Empiema
- Bakteremia
- Perikarditis
- Radang Sendi
Precautions and warnings
Penisilin harus dikonsumsi dengan hati-hati pada orang yang memiliki riwayat alergi parah atau asma.
Pemberian intravena atau intraarterial, serta suntikan ke dalam atau di dekat saraf perifer utama atau arteri darah, harus dihindari karena dapat menyebabkan cedera neurovaskular.
Side-effects
- Seperti halnya penisilin lainnya
- reaksi fenomena sensitivitas yang tidak diinginkan mungkin terjadi
- terutama pada individu yang sebelumnya menunjukkan hipersensitivitas terhadap penisilin atau pada mereka yang memiliki riwayat alergi
- asma
- demam
- atau urtikaria. Berikut ini telah dilaporkan dengan penisilin G parenteral: Umum: Reaksi hipersensitivitas termasuk yang berikut: erupsi kulit (dermatitis makulopapular hingga eksfoliatif)
- urtikaria
- edema laring
- demam
- eosinofilia; reaksi mirip penyakit serum lainnya (termasuk menggigil
- demam
- edema
- arthralgia
- dan sujud); dan anafilaksis termasuk syok dan kematian. Gastrointestinal: Kolitis pseudomembran. Timbulnya gejala kolitis pseudomembran dapat terjadi selama atau setelah pengobatan antibakteri.
Drug Interactions
Meningkatkan dan memperpanjang kadar penisilin serum dengan probenesid.
Tetrasiklin dapat melawan efek bakterisidal penisilin.
Contraindications
Reaksi hipersensitif terhadap penisilin atau prokain di masa lalu merupakan kontraindikasi.
Mode of actions
Bakteri gram positif, kokus gram negatif, beberapa bakteri gram negatif lainnya, spirochetes, dan actinomycetes semuanya rentan terhadap benzilpenisilin. Ini menghambat sintesis dinding sel bakteri dengan mengikat dan menonaktifkan transpeptidase pada permukaan bagian dalam membran sel bakteri, mencegah tahap akhir biosintesis peptidoglikan ikatan silang. Penisilinase dan?-laktamase lainnya adalah inhibitor.
Mengganggu sintesis mukopeptida di dinding sel selama penggandaan aktif, menghasilkan tindakan bakterisida terhadap bakteri sensitif.
Dosage & Administration
Infeksi Streptokokus Grup A-Infeksi pada saluran pernapasan bagian atas, infeksi kulit dan jaringan lunak, demam berdarah, dan erisipelas.
Dosis berikut direkomendasikan:
Pasien dewasa dan anak-anak dengan berat lebih dari 60 lbs. beratnya: 2.400.000 unit.
Pasien anak dengan berat 30 hingga 60 pon: 900.000 unit hingga 1.200.000 unit.
Pasien anak di bawah 30 lbs.: 600.000 unit.
CATATAN: Pengobatan dengan dosis yang dianjurkan biasanya diberikan dalam satu sesi menggunakan beberapa situs IM bila diindikasikan. Jadwal dosis alternatif dapat digunakan, memberikan setengah (1/2) dosis total pada hari ke-1 dan satu setengah (1/2) pada hari ke-3.
Infeksi Pneumokokus (kecuali meningitis pneumokokus)
600.000 unit pada pasien anak dan 1.200.000 unit pada dewasa, diulang setiap 2 atau 3 hari hingga suhu normal selama 48 jam. Bentuk penisilin lain mungkin diperlukan untuk kasus yang parah.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan telah menunjukkan efek buruk bahkan terkadang tidak dapat menunjukkan risiko pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan hanya jika benar-benar diperlukan.
Diskusikan dengan dokter Anda dan beri tahu mereka tanggapan tentang obat ini.
Belum ada informasi spesifik apakah obat ini ditularkan ke bayi melalui ASI. Diskusikan dengan dokter Anda sebelum menyusui.
Pack Size & Price
1 vial pack Price : ৳9.1
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