Pronapen 8 LAC (Injection)
Manufactured by: Renata Limited
Benzyl Penicillin + Procaine Penicillin Similar medicine
Pronapen 8 LAC is indicated for
- Менингит
- Перитонит
- Сибирская язва
- Негонококковый уретрит
- Дифтерия
- Сифилис
- Инфекции
- вызванные стафилококком (чувствительные штаммы)
- Стрептококк
- Гонорея видов пневмококка
- Подострый бактериальный эндокардит
- Верхние дыхательные пути
- Рожа
- Инфекции кожи и мягких тканей
- Среднетяжелая пневмония и средний отит
- Эмпиема
- Бактеремия
- Перикардит
- Артрит
Precautions and warnings
Пенициллин следует принимать с осторожностью людям, у которых в анамнезе есть тяжелая аллергия или астма.
Следует избегать внутривенного или внутриартериального введения, а также инъекций в крупные периферические нервы или кровеносные артерии или вблизи них, поскольку они могут вызвать сосудисто-нервное повреждение.
Side-effects
- Как и в случае с другими пенициллинами
- вероятно возникновение нежелательных реакций
- связанных с явлениями чувствительности
- особенно у лиц
- у которых ранее наблюдалась гиперчувствительность к пенициллинам
- или у лиц с аллергией
- астмой
- сенной лихорадкой или крапивницей в анамнезе. Сообщалось о следующих случаях парентерального введения пенициллина G: Общие сведения: реакции гиперчувствительности
- включая следующие: кожные высыпания (макулопапулезный или эксфолиативный дерматит)
- крапивница
- отек гортани
- лихорадка
- эозинофилия; другие реакции
- подобные сывороточной болезни (включая озноб
- лихорадку
- отеки
- артралгии и прострацию); и анафилаксия
- включая шок и смерть. Желудочно-кишечный тракт: псевдомембранозный колит. Симптомы псевдомембранозного колита могут возникнуть во время или после антибактериального лечения.
Drug Interactions
Пробенецид повышает и продлевает уровень пенициллина в сыворотке.
Тетрациклин может противодействовать бактерицидному эффекту пенициллина.
Contraindications
Любая реакция гиперчувствительности к пенициллину или новокаину в прошлом является противопоказанием.
Mode of actions
Грамположительные бактерии, грамотрицательные кокки, некоторые другие грамотрицательные бактерии, спирохеты и актиномицеты чувствительны к бензилпенициллину. Он ингибирует синтез клеточной стенки бактерий путем связывания и инактивации транспептидаз на внутренней поверхности мембраны бактериальных клеток, предотвращая заключительную стадию поперечного сшивания биосинтеза пептидогликана. Пенициллиназа и другие β-лактамазы являются ингибиторами.
Препятствует синтезу мукопептидов в клеточной стенке во время активного размножения, что приводит к бактерицидному действию в отношении чувствительных бактерий.
Dosage & Administration
Стрептококковые инфекции группы А — инфекции верхних дыхательных путей, кожи и мягких тканей, скарлатина, рожа.
Рекомендуются следующие дозы:
Взрослые и педиатрические пациенты весом более 60 фунтов. в весе: 2 400 000 единиц.
Педиатрические пациенты от 30 до 60 фунтов: от 900 000 до 1 200 000 единиц.
Педиатрические пациенты весом до 30 фунтов: 600 000 единиц.
ПРИМЕЧАНИЕ. Лечение в рекомендуемой дозировке обычно проводится за один сеанс с использованием нескольких мест внутримышечного введения при наличии показаний. Можно использовать альтернативный график дозирования, включающий половину (1/2) общей дозы в 1-й день и половину (1/2) в 3-й день.
Пневмококковые инфекции (кроме пневмококкового менингита)
600 000 ЕД у детей и 1 200 000 ЕД у взрослых, повторяют каждые 2 или 3 дня до нормализации температуры в течение 48 часов. В тяжелых случаях могут потребоваться другие формы пенициллина.
Pregnancy & Lactation
Хотя исследования на репродукции животных показали неблагоприятное воздействие, иногда даже неспособное продемонстрировать риск для плода, а адекватных и хорошо контролируемых исследований у беременных женщин не проводилось, во время беременности это лекарство можно применять только тогда, когда это определенно необходимо.
Обсудите это со своими врачами и расскажите им отзывы об этом лекарстве.
Нет конкретной информации о том, передается ли это лекарство ребенку через грудное молоко. Перед кормлением грудью обсудите это с врачом.
Pack Size & Price
1 vial pack Price : ৳9.1
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