Pronapen 8 LAC (Injection)
Manufactured by: Renata Limited
Benzyl Penicillin + Procaine Penicillin Similar medicine
Pronapen 8 LAC is indicated for
- Meningitis
- peritonitis
- ántrax
- uretritis no gonocócica
- difteria
- sífilis
- infecciones causadas por estafilococos (cepas sensibles)
- estreptococos
- neumococos gonorrea
- endocarditis bacteriana subaguda
- tracto respiratorio superior
- erisipela
- infecciones de la piel y tejidos blandos
- neumonía y otitis media moderadamente graves
- empiema
- bacteriemia
- pericarditis
- artritis
Precautions and warnings
La penicilina debe tomarse con precaución en personas que tienen antecedentes de alergias graves o asma.
Debe evitarse la administración intravenosa o intraarterial, así como las inyecciones en o cerca de los principales nervios periféricos o arterias sanguíneas, porque pueden causar lesiones neurovasculares.
Side-effects
- Al igual que con otras penicilinas
- es probable que se produzcan reacciones adversas del fenómeno de sensibilidad
- particularmente en individuos que previamente han demostrado hipersensibilidad a las penicilinas o en aquellos con antecedentes de alergia
- asma
- fiebre del heno o urticaria. Se ha informado lo siguiente con penicilina G parenteral: General: Reacciones de hipersensibilidad que incluyen las siguientes: erupciones cutáneas (dermatitis maculopapular a exfoliativa)
- urticaria
- edema laríngeo
- fiebre
- eosinofilia; otras reacciones similares a la enfermedad del suero (incluidos escalofríos
- fiebre
- edema
- artralgia y postración); y anafilaxia
- incluido shock y muerte. Gastrointestinal: colitis pseudomembranosa. La aparición de síntomas de colitis pseudomembranosa puede ocurrir durante o después del tratamiento antibacteriano.
Drug Interactions
Aumenta y prolonga los niveles séricos de penicilina con probenecid.
La tetraciclina puede contrarrestar el efecto bactericida de la penicilina.
Contraindications
Cualquier reacción de hipersensibilidad a la penicilina o la procaína en el pasado es una contraindicación.
Mode of actions
Las bacterias grampositivas, los cocos gramnegativos, algunas otras bacterias gramnegativas, las espiroquetas y los actinomicetos son todos susceptibles a la bencilpenicilina. Inhibe la síntesis de la pared celular bacteriana uniendo e inactivando las transpeptidasas en la superficie interna de la membrana celular bacteriana, previniendo la etapa final de reticulación de la biosíntesis de peptidoglicano. La penicilinasa y otras β-lactamasas son inhibidores.
Interfiere con la síntesis de mucopéptidos en la pared celular durante la multiplicación activa, lo que resulta en una acción bactericida contra bacterias sensibles.
Dosage & Administration
Infecciones estreptocócicas Grupo A: Infecciones del tracto respiratorio superior, infecciones de la piel y tejidos blandos, escarlatina y erisipela.
Se recomiendan las siguientes dosis:
Adultos y pacientes pediátricos de más de 60 libras. en peso: 2.400.000 unidades.
Pacientes pediátricos de 30 a 60 lbs.: 900.000 unidades a 1.200.000 unidades.
Pacientes pediátricos menores de 30 lbs.: 600.000 unidades.
NOTA: El tratamiento con la dosis recomendada generalmente se administra en una sola sesión utilizando múltiples sitios IM cuando esté indicado. Se puede utilizar un esquema de dosificación alternativo, administrando la mitad (1/2) de la dosis total el día 1 y la mitad (1/2) el día 3.
Infecciones neumocócicas (excepto meningitis neumocócica)
600.000 unidades en pacientes pediátricos y 1.200.000 unidades en adultos, repetidos cada 2 o 3 días hasta que la temperatura se normalice durante 48 horas. En casos graves pueden ser necesarias otras formas de penicilina.
Pregnancy & Lactation
Aunque los estudios de reproducción en animales han demostrado efectos adversos, incluso a veces no se puede demostrar el riesgo para el feto y no existen estudios adecuados y bien controlados en mujeres embarazadas, durante el embarazo este medicamento se puede utilizar sólo cuando sea definitivamente necesario.
Hable con sus médicos y cuénteles sus comentarios sobre este medicamento.
No existe información específica sobre si este medicamento se transmite al bebé a través de la leche materna. Hable con su médico antes de amamantar.
Pack Size & Price
1 vial pack Price : ৳9.1
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