Vitilen 10 mg/ml (Lotion)
Manufactured by: Ziska Pharmaceuticals Ltd.
Methoxsalen Similar medicine
Vitilen is indicated for
- Psoriasis
- vitiligo
- eczéma
- lymphome à cellules T
Precautions and warnings
Ce médicament ne doit être utilisé que pour traiter le psoriasis sévère qui ne s’est pas amélioré avec d’autres traitements, car il peut provoquer des effets secondaires graves comme des cataractes et un risque accru de cancer de la peau ou de vieillissement cutané prématuré.
Les patients doivent éviter de prendre un bain de soleil dans les 24 heures précédant la prise de méthoxsalène et un traitement UV. Après un coup de soleil, il peut être difficile pour les médecins d'évaluer correctement l'efficacité de la photochimiothérapie.
Side-effects
- Des nausées ou des troubles du sommeil peuvent survenir avec le méthoxsalène. De légères démangeaisons
- un dessèchement
- une rougeur ou un assombrissement de la peau peuvent survenir lorsque le méthoxsalène est utilisé avec un traitement par lumière UVA. Des effets secondaires peu probables mais graves surviennent : rougeur sévère de la peau
- cloques/desquamation/brûlure de la peau
- amincissement/rides de la peau
- brunissement/blanchiment/jaunissement douloureux des ongles
- gonflement des chevilles
- changements mentaux/d'humeur (tels que dépression
- nervosité).
Drug Interactions
Les médicaments pouvant provoquer une photosensibilité, tels que l'anthraline, le goudron de houille et ses dérivés, la griséofulvine, les phénothiazines, l'acide nalidixique, les sulfamides, les tétracyclines et les diurétiques thiazidiques, peuvent avoir des effets secondaires plus importants lorsqu'ils sont utilisés ensemble. Ce médicament peut également augmenter les niveaux ou les effets d'autres médicaments, notamment l'aminophylline, la fluvoxamine, la mexilétine, la mirtazapine, le ropinirole, la théophylline, la trifluopérazine, la dexmédétomidine et l'ifosfamide.
Mode of actions
Le méthoxsalène rend la peau plus sensible aux rayons UV de grande longueur d'onde. Il s’attache à l’ADN et empêche sa production, ce qui empêche également les cellules de se diviser. Cela peut causer des dommages aux cellules. Cette propriété du méthoxsalène est utilisée dans un traitement appelé photochimiothérapie, ou PUVA, où le médicament (psoralène) est combiné à une forte lumière UVA.
Dosage & Administration
Pour la forme posologique de solution topique :
Pour le vitiligo : Adultes et enfants de 12 ans et plus – Appliquer sur la zone affectée de la peau et laisser sécher pendant une à deux minutes, puis appliquer à nouveau dans les deux heures à deux heures et demie avant l'exposition aux UVA.
La lotion Methoxsalen est appliquée uniquement sur de petites lésions bien définies et de préférence sur des lésions qui peuvent être protégées par des vêtements ou un écran solaire contre une exposition ultérieure aux UVA.
Ne prenez pas de soleil pendant 24 heures avant de prendre du méthoxsalène et de suivre un traitement par lumière UVA. Prenez ce médicament par voie orale avec de la nourriture ou du lait, généralement 2 à 4 heures avant votre traitement par lumière UVA ou selon les directives de votre médecin.
La posologie du méthoxsalène dépend du poids, de l'état de santé et de la réponse au traitement. La quantité et la durée de la lumière UVA pour chaque traitement dépendent du type de peau et de la réponse au traitement. Le patient peut recevoir des traitements aux rayons UVA 2 à 4 fois par semaine au début, puis moins fréquemment à mesure que son état s'améliore.
Pregnancy & Lactation
Bien que des études sur la reproduction animale aient montré un effet indésirable sur le fœtus et qu'il n'existe pas d'études adéquates et bien contrôlées chez la femme enceinte, ce médicament peut être utilisé pendant la grossesse juste lorsque cela est absolument nécessaire, malgré les risques potentiels.
Les mères d'un nouveau-né qui ont utilisé ce médicament au cours des 3 derniers mois de leur grossesse peuvent rarement créer des symptômes tels que somnolence, raideur ou tremblements musculaires, troubles de l'alimentation ou de la respiration, pleurs constants. Si vous remarquez l'un de ces symptômes chez votre bébé, en particulier au cours de son premier mois, informez-en immédiatement le médecin.
Ce médicament passe dans le lait maternel. Parlez-en à votre médecin avant d'allaiter.
Pack Size & Price
1's pack Price : ৳300
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Manufactured by: Ziska Pharmaceuticals Ltd.
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