Vitilen 10 mg/ml (Lotion)
Manufactured by: Ziska Pharmaceuticals Ltd.
Methoxsalen Similar medicine
Vitilen is indicated for
- Psoriasis
- Vitiligo
- Eksim
- Limfoma Sel T
Precautions and warnings
Obat ini hanya boleh digunakan untuk mengobati psoriasis parah yang belum membaik dengan pengobatan lain, karena dapat menyebabkan efek samping yang serius seperti katarak dan peningkatan risiko kanker kulit atau penuaan kulit dini.
Pasien sebaiknya menghindari berjemur dalam 24 jam sebelum mengonsumsi methoxsalen dan menjalani perawatan UV. Mengalami luka bakar akibat sinar matahari dapat menyulitkan dokter untuk menilai dengan tepat seberapa baik kerja fotokemoterapi.
Side-effects
- Mual atau kesulitan tidur dapat terjadi dengan methoxsalen. Gatal ringan/pengeringan/kemerahan/penggelapan kulit dapat terjadi ketika methoxsalen digunakan bersamaan dengan perawatan sinar UVA. Efek samping yang jarang terjadi namun serius: kulit menjadi sangat merah
- kulit melepuh/terkelupas/terbakar
- kulit menipis/keriput
- kuku menjadi coklat/memutih/menguning
- pergelangan kaki bengkak
- perubahan mental/suasana hati (seperti depresi
- gugup).
Drug Interactions
Obat-obatan yang dapat menyebabkan fotosensitifitas, seperti anthralin, tar batubara dan turunannya, griseofulvin, fenotiazin, asam nalidiksat, sulfonamid, tetrasiklin, dan diuretik thiazide, mungkin memiliki efek samping yang lebih kuat bila digunakan bersamaan. Obat ini juga dapat meningkatkan kadar atau efek obat lain, termasuk aminofilin, fluvoxamine, mexiletine, mirtazapine, ropinirole, teofilin, trifluoperazine, dexmedetomidine, dan ifosfamide.
Mode of actions
Methoxsalen membuat kulit lebih sensitif terhadap sinar UV gelombang panjang. Ia menempel pada DNA dan menghentikan pembuatan DNA, yang juga mencegah pembelahan sel. Hal ini dapat menyebabkan beberapa kerusakan pada sel. Sifat methoxsalen ini digunakan dalam pengobatan yang disebut fotokemoterapi, atau PUVA, dimana obat (psoralen) dikombinasikan dengan sinar UVA yang kuat.
Dosage & Administration
Untuk bentuk sediaan larutan topikal:
Untuk vitiligo: Dewasa dan anak-anak berusia 12 tahun ke atas—Oleskan pada area kulit yang terkena dan biarkan mengering selama satu hingga dua menit, lalu oleskan kembali dalam waktu dua hingga dua setengah jam sebelum paparan UVA.
Lotion methoxsalen hanya diaplikasikan pada lesi kecil yang berbatas tegas dan sebaiknya pada lesi yang dapat dilindungi oleh pakaian atau tabir surya dari paparan UVA selanjutnya.
Jangan berjemur selama 24 jam sebelum mengonsumsi methoxsalen dan menjalani perawatan sinar UVA. Minum obat ini melalui mulut dengan makanan atau susu, biasanya 2 hingga 4 jam sebelum perawatan sinar UVA atau sesuai anjuran dokter.
Dosis methoxsalen didasarkan pada berat badan, kondisi medis, dan respons terhadap pengobatan. Jumlah dan waktu paparan sinar UVA untuk setiap perawatan didasarkan pada jenis kulit dan respons terhadap perawatan. pasien mungkin menjalani perawatan sinar UVA 2 hingga 4 kali seminggu saat pertama kali memulai dan kemudian lebih jarang lagi saat kondisinya membaik.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Ibu dengan bayi baru lahir yang telah menggunakan obat ini selama 3 bulan terakhir kehamilan mungkin jarang mengalami gejala termasuk mengantuk, otot kaku atau gemetar, kesulitan makan atau bernapas, dan menangis terus-menerus. Jika Anda melihat gejala-gejala ini pada bayi Anda terutama pada bulan pertama, segera beri tahu dokter.
Obat ini masuk ke dalam ASI. Bicaralah dengan dokter Anda sebelum menyusui.
Pack Size & Price
1's pack Price : ৳300
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Manufactured by: Ziska Pharmaceuticals Ltd.
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