Vitilen 10 mg/ml (Lotion)
Manufactured by: Ziska Pharmaceuticals Ltd.
Methoxsalen Similar medicine
Vitilen is indicated for
- Psoríase
- Vitiligo
- Eczema
- Linfoma de Células T
Precautions and warnings
Este medicamento só deve ser usado para tratar a psoríase grave que não melhorou com outros tratamentos, porque pode causar efeitos colaterais graves como catarata e aumento do risco de câncer de pele ou envelhecimento prematuro da pele.
Os pacientes devem evitar tomar sol nas 24 horas antes de tomar metoxsalen e se submeter ao tratamento UV. Ter uma queimadura solar pode dificultar a avaliação adequada do médico sobre o funcionamento da fotoquimioterapia.
Side-effects
- Náuseas ou dificuldade para dormir podem ocorrer com metoxsaleno. Pode ocorrer leve coceira/ressecamento/vermelhidão/escurecimento da pele quando o metoxsaleno é usado junto com o tratamento com luz UVA. Ocorrem efeitos colaterais improváveis
- mas graves: vermelhidão grave da pele
- bolhas / descamação / queimação na pele
- adelgaçamento / enrugamento da pele
- escurecimento / branqueamento / amarelecimento doloroso das unhas
- inchaço dos tornozelos
- alterações mentais / de humor (como depressão
- nervosismo).
Drug Interactions
Medicamentos que podem causar fotossensibilidade, como antralina, alcatrão de carvão e seus derivados, griseofulvina, fenotiazinas, ácido nalidíxico, sulfonamidas, tetraciclinas e diuréticos tiazídicos, podem ter efeitos colaterais mais fortes quando usados em conjunto. Este medicamento também pode aumentar os níveis ou efeitos de outros medicamentos, incluindo aminofilina, fluvoxamina, mexiletina, mirtazapina, ropinirol, teofilina, trifluoperazina, dexmedetomidina e ifosfamida.
Mode of actions
Metoxsalen torna a pele mais sensível aos raios UV de longo comprimento de onda. Ele se liga ao DNA e impede a produção de DNA, o que também impede a divisão das células. Isso pode causar alguns danos às células. Essa propriedade do metoxsalen é usada em um tratamento chamado fotoquimioterapia, ou PUVA, onde o medicamento (psoraleno) é combinado com forte luz UVA.
Dosage & Administration
Para forma farmacêutica de solução tópica:
Para vitiligo: Adultos e crianças com 12 anos ou mais de idade – Aplique na área afetada da pele e deixe secar por um a dois minutos, depois aplique novamente dentro de duas a duas horas e meia antes da exposição UVA.
A loção Metoxsaleno é aplicada apenas em lesões pequenas e bem definidas e preferencialmente em lesões que podem ser protegidas por roupas ou protetor solar contra posterior exposição aos UVA.
Não tome sol por 24 horas antes de tomar metoxsaleno e fazer o tratamento com luz UVA. Tome este medicamento por via oral com alimentos ou leite, geralmente 2 a 4 horas antes do tratamento com luz UVA ou conforme indicado pelo seu médico.
A dosagem de metoxsalen é baseada no peso, condição médica e resposta ao tratamento. A quantidade e o tempo de luz UVA para cada tratamento são baseados no tipo de pele e na resposta ao tratamento. o paciente pode fazer tratamentos com luz UVA 2 a 4 vezes por semana no início e depois com menos frequência à medida que a condição melhora.
Pregnancy & Lactation
Embora estudos de reprodução animal tenham demonstrado um efeito adverso no feto e não existam estudos adequados e bem controlados em mulheres grávidas, mas durante a gravidez, este medicamento pode ser utilizado apenas quando definitivamente necessário, apesar dos riscos potenciais.
As mães com um bebê recém-nascido que usaram este medicamento durante os últimos 3 meses de gravidez raramente podem apresentar sintomas incluindo sonolência, rigidez ou tremores musculares, problemas de alimentação ou respiração, choro constante. Se você notar algum destes sintomas em seu bebê, especialmente durante o primeiro mês, informe o médico imediatamente.
Este medicamento passa para o leite materno. Converse com seu médico antes de amamentar.
Pack Size & Price
1's pack Price : ৳300
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Manufactured by: Ziska Pharmaceuticals Ltd.
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