Demarin 600mg (Tablet)
Manufactured by: ACI Limited
Oxaprozin Similar medicine
Demarin is indicated for
- Artritis reumatoid
- Osteoartritis
- Artritis reumatoid remaja
Precautions and warnings
Waspadai bisul dan pendarahan pada pasien yang mengonsumsi obat ini dalam jangka waktu lama. Berhati-hatilah terutama jika pasien mempunyai riwayat masalah lambung atau usus yang serius, minum alkohol, merokok, atau mempunyai risiko tukak lambung lainnya. Orang yang berusia lanjut, lemah, mengalami gagal jantung yang tidak terkontrol, tekanan darah tinggi, gangguan jantung, sedang mengonsumsi pil air putih dalam jangka panjang, atau memiliki kondisi yang menyebabkan retensi cairan juga memerlukan perhatian khusus. Gunakan dengan hati-hati pada pasien dengan masalah ginjal atau hati. Hati-hati pada pasien dengan gangguan perdarahan atau pasien yang menjalani operasi yang memerlukan kontrol perdarahan yang cermat. Jangan gunakan obat ini pada trimester ketiga kehamilan, dan hindari saat menyusui.
Side-effects
- Depresi
- sedasi
- mengantuk
- kebingungan
- gangguan tidur
- kelemahan
- malaise; ruam
- prutitus
- urtikaria
- fotosensitifitas; sakit/distress perut
- anoreksia
- perut kembung
- muntah
- sembelit
- diare
- pencernaan yg terganggu
- mual
- tukak lambung dan/atau perdarahan GI
- kelainan pada LFT
- stomatitis
- perdarahan hemoroid atau dubur; tinitus; disuria atau frekuensi; edema
- perubahan tekanan darah; hematuria
- insufisiensi ginjal
- penurunan aliran menstruasi; anemia
- trombositopenia
- leukopenia
- ekimosis; berapa keuntungan/kerugian; penglihatan kabur
- konjungtivitis. Berpotensi Fatal: Reaksi anafilaktoid
- dermatitis eksfoliatif
- sindrom Stevens-Johnson
- nekrolisis epidermal toksik
- reaksi hati yang parah.
Drug Interactions
Ada kemungkinan lebih tinggi keracunan salisilat saat mengonsumsi aspirin. Obat ini bisa membuat efek pengencer darah oral menjadi lebih kuat. Ini mungkin membuat beta-blocker, diuretik, dan obat lain untuk tekanan darah tinggi menjadi kurang efektif. Hal ini juga dapat meningkatkan risiko toksisitas dari metotreksat dan litium.
Contraindications
Riwayat tukak lambung (dulu atau sekarang) atau alergi terhadap NSAID. Selain itu, jangan gunakan untuk mengatasi rasa sakit di sekitar waktu operasi cangkok bypass arteri koroner (CABG).
Mode of actions
Oxaprozin merupakan salah satu jenis NSAID (obat antiinflamasi nonsteroid) yang berasal dari asam propionat. Ia bekerja dengan memblokir enzim yang disebut siklooksigenase, yang menghentikan produksi prostaglandin—bahan kimia dalam tubuh yang menyebabkan rasa sakit dan peradangan.
Dosage & Administration
Dewasa: PO Osteoartritis 1,2 g sekali sehari. Pasien dengan berat badan rendah atau penyakit ringan: Awal: 600 mg sekali sehari. Maks: 1,8 g atau 26 mg/kg (mana yang lebih rendah) dalam dosis terbagi.
Artritis reumatoid 1,2 g sekali sehari. Maks: 1,8 g atau 26 mg/kg (mana yang lebih rendah) dalam dosis terbagi.
Artritis reumatoid remaja
Anak: >6 tahun: Berat 22-31 kg: 600 mg; 32-54kg: 900mg; >55kg: 1200mg. Semua dosis harus diberikan sekali sehari.
Pregnancy & Lactation
Obat ini tidak diperbolehkan selama kehamilan. Jangan gunakan jika Anda sedang hamil. Dapat diserap melalui kulit dan paru-paru sehingga dapat merusak organ tubuh anak Anda yang belum lahir dan menyebabkan cacat bawaan. Alat kontrasepsi yang efektif dan ketat selama pengobatan dan selama enam bulan setelah menghentikan obat ini. Jika Anda hamil, hentikan penggunaan obat ini dan segera diskusikan dengan dokter Anda.
Belum ada informasi spesifik apakah obat ini masuk ke dalam ASI atau tidak. Mengingat kemungkinan risiko pada anak-anak, menyusui saat menggunakan obat ini tidak dianjurkan dan setidaknya dua minggu setelah dosis terakhir. Konsultasikan dengan dokter Anda sebelum menyusui.
Pack Size & Price
30's pack Price : ৳210.9
Similar medicine
Manufactured by: Eskayef Bangladesh Ltd.
Manufactured by: ACI Limited
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