Precautions and warnings

Before taking this medication, it is essential to take the following precautions:

Inform your healthcare provider if you have any allergies to pizotifen or any other medications.

Let your doctor know if you are taking any other medications, including prescription, over-the-counter, and herbal products, as they may interact with pizotifen.

Inform your doctor about any medical conditions you have, including liver disease, kidney disease, heart disease, and epilepsy.

Pizotifen may cause drowsiness, so it is important to avoid driving or operating heavy machinery until you know how the medication affects you.

Pizotifen can cause weight gain, so it is important to follow a healthy diet and exercise regularly to avoid excessive weight gain.

If you are pregnant or breastfeeding, talk to your doctor before taking pizotifen. The medication may harm the developing fetus or pass into breast milk and affect the nursing baby.

Alcohol can increase the risk of side effects such as drowsiness and dizziness when taking pizotifen, so it is important to limit or avoid alcohol consumption while taking this medication.

It is important to take pizotifen exactly as prescribed by your doctor. Do not stop taking the medication before completing the full course of treatment, even if you start feeling better.

Drug Interactions

Pizotifen can interact with several medications, including prescription, over-the-counter, and herbal products. Some of the significant drug interactions of Pizotifen include:

Monoamine oxidase inhibitors (MAOIs): Taking pizotifen with MAOIs, a class of medications used to treat depression, can cause serotonin syndrome, a potentially life-threatening condition.

Antidepressants: Pizotifen can interact with selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and other antidepressants, leading to increased serotonin levels and the risk of serotonin syndrome.

Sedatives and alcohol: Pizotifen can cause drowsiness, so it should not be taken with sedatives, sleeping pills, or alcohol, as these can further increase the risk of drowsiness and impaired cognitive function.

Antihistamines: Taking pizotifen with other antihistamines can increase the risk of side effects such as dry mouth, blurred vision, and constipation.

Blood pressure medications: Pizotifen can interact with medications used to treat high blood pressure, such as beta-blockers, leading to decreased blood pressure.

Narcotic pain medications: Pizotifen can interact with narcotic pain medications, such as codeine and morphine, leading to increased drowsiness and respiratory depression.

Contraindications

Pizotifen is contraindicated in certain individuals, which means that it should not be used in these situations:

Hypersensitivity: Pizotifen should not be used in individuals who are allergic to the medication or any of its ingredients.

Pregnancy and breast-feeding: Pizotifen should not be used during pregnancy or breastfeeding unless specifically prescribed by a doctor.

Cardiovascular disease: Pizotifen should not be used in individuals with a history of heart disease, including heart attack, heart failure, or arrhythmias.

Liver disease: Pizotifen should not be used in individuals with severe liver disease.

Epilepsy: Pizotifen should not be used in individuals with epilepsy or a history of seizures.

Glaucoma: Pizotifen should not be used in individuals with narrow-angle glaucoma.

Urinary retention: Pizotifen should not be used in individuals with urinary retention or bladder neck obstruction.

Children under 2 years of age: Pizotifen is not recommended for use in children under 2 years of age.

Mode of actions

Pizotifen is a sedating antihistamine with strong serotonin antagonist and weak antimuscarinic properties. It also antagonises the action of tryptamine.

Dosage & Administration

Oral
Prophylaxis of migraine, Prophylaxis of cluster headache
Adult: 1.5 mg/day either in 3 divided doses or as a single dose at night. A gradual increase of 0.5 mg helps to avoid drowsiness. Max dose: 4.5 mg/day and 3 mg/dose.

Child: less than 2 yr: Up to 1.5 mg daily in divided doses. Max dose: 1 mg/dose.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

Pack Size & Price