Nifedipine 10 mg (Tablet)
Manufactured by: Albion Laboratories Ltd.
Nifedipine Similar medicine
Nifedipine is indicated for
- Hipertensi
- Angina pectoris
- sindrom Raynaud
- Pencegahan stroke
Precautions and warnings
Tekanan darah rendah, fungsi jantung lemah, atau gagal jantung (yang bisa menjadi lebih buruk), penyempitan katup aorta yang parah, masalah hati, diabetes, porfiria, dan kehamilan adalah kondisi-kondisi yang harus diwaspadai. Jangan berhenti minum obat ini secara tiba-tiba, karena dapat memperparah nyeri dada (angina). Jika nyeri dada akibat kurangnya aliran darah ke jantung terjadi setelah minum obat, hentikan penggunaannya.
Side-effects
- Edema perifer
- hipotensi
- jantung berdebar
- takikardia
- muka memerah
- pusing
- sakit kepala
- mual
- peningkatan frekuensi berkemih
- lesu
- nyeri mata
- depresi mental
- gangguan penglihatan
- hiperplasia gingiva
- mialgia
- tremor
- impotensi
- demam
- peningkatan paradoks nyeri dada iskemik saat memulai pengobatan
- ruam
- kelainan fungsi hati (termasuk kolestasis)
- obstruksi GI pada beberapa tablet bersalut membran yang tidak dapat dicerna.
Drug Interactions
Efek penurunan tekanan darah lebih kuat bila obat ini dikonsumsi dengan obat antihipertensi lain, aldesleukin, atau antipsikotik. Jika digunakan dengan fentanil selama operasi, dapat menyebabkan tekanan darah rendah yang berbahaya. Obat ini dapat memengaruhi respons tubuh Anda terhadap insulin dan glukosa. Ketika dikonsumsi dengan benazepril, obat ini mengurangi efek detak jantung cepat yang diharapkan. Mengonsumsinya dengan pengencer darah kumarin dapat meningkatkan risiko pendarahan. Kadar obat dalam darah Anda dapat meningkat jika Anda menggunakan obat yang memblokir CYP3A4 (seperti beberapa antijamur, cimetidine, eritromisin, penghambat protease HIV, nefazodone, fluoxetine, atau quinupristin/dalfopristin).
Bahaya: Penginduksi CYP3A4 (seperti rifampisin, fenitoin, atau karbamazepin) dapat menurunkan efek obat ini dan membuatnya kurang efektif.
Contraindications
Digunakan untuk:
- Serangan jantung akut (MI)
- Syok kardiogenik (kondisi serius dimana jantung tidak dapat memompa cukup darah)
- Nyeri dada yang tiba-tiba dan tidak stabil (angina tidak stabil)
- Mengobati nyeri dada pada penyakit jantung kronis (jangka panjang) (angina stabil kronis)
Mode of actions
Nifedipine bekerja dengan menghalangi ion kalsium memasuki jantung dan sel otot polos selama depolarisasi. Tindakan ini membantu merelaksasi dan memperlebar pembuluh darah (baik di tubuh maupun di jantung), menurunkan tekanan darah dan mengurangi resistensi pada arteri (afterload). Ini juga meningkatkan aliran darah ke jantung. Namun, tubuh mungkin merespons dengan meningkatkan detak jantung (refleks takikardia). Nifedipine biasanya tidak mempengaruhi perjalanan sinyal listrik melalui jantung dan jarang melemahkan kekuatan kontraksi jantung.
Dosage & Administration
Dewasa: PO HTN extended release 10-40 mg dua kali sehari atau 20-90 mg sekali sehari. Angina pectoris extended release 10-40 mg dua kali sehari atau 30-90 mg sekali sehari. Tutup berisi cairan: 5-20 mg 3 kali/hari. Sindrom Raynaud Tutup berisi cairan: 5-20 mg 3 kali/hari.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Ibu dengan bayi baru lahir yang telah menggunakan obat ini selama 3 bulan terakhir kehamilan mungkin jarang mengalami gejala termasuk mengantuk, otot kaku atau gemetar, kesulitan makan atau bernapas, dan menangis terus-menerus. Jika Anda melihat gejala-gejala ini pada bayi Anda terutama pada bulan pertama, segera beri tahu dokter.
Obat ini masuk ke dalam ASI. Bicaralah dengan dokter Anda sebelum menyusui.
Pack Size & Price
100's pack Price : ৳
Similar medicine
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Manufactured by: Albion Laboratories Ltd.
Manufactured by: Square Pharmaceuticals Ltd.
Manufactured by: Drug International Ltd.
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