Difenac PLUS IM (Injection)
Manufactured by: Rephco Pharmaceuticals Ltd.
Diclofenac + Lidocaine Hydrochloride Similar medicine
Difenac PLUS IM is indicated for
- Rheumatoide Arthritis
- Arthrose
- Ankylosspondylitis
- Schmerzen
- akute Gicht
- Entzündung
- Tendinitis
- Actinic -Keratosen
- Bursitis
Precautions and warnings
Menschen mit Magengeschwüren, Erbrechen von Blut, schwarzen Stühlen, Colitis ulcerosa, Asthma oder Asthma in der Vergangenheit, Morbus Crohn, Blutungsproblemen oder Blutstörungen müssen vorsichtig sein. Diejenigen, die schwerwiegende Leber-, Herz- oder Nierenprobleme haben, sind ältere Menschen oder die aktuellen oder vergangenen Bluthochdruck haben, sollten genau beobachtet werden. Jeder, der lange Zeit NSAIDs (wie Diclofenac Natrium) einnimmt, sollte regelmäßige Untersuchungen haben, einschließlich Tests auf Nieren-, Leber- und Blutfunktion. Wenn Lebertests abnormal bleiben, schlechter werden oder Symptome einer Lebererkrankung auftreten, sollte Diclofenac -Natrium gestoppt werden.
Side-effects
- Nebenwirkungen von Diclofenac sind normalerweise mild und vorübergehend. Es ist im Allgemeinen gut vertragen. Zu Beginn der Behandlung können die Patienten jedoch manchmal über gastrointestinale Beschwerden
- Epigastria -Schmerzen
- Aufruhr
- Übelkeit und Durchfall
- Kopfschmerzen und Blutungen auftreten. Gelegentlich wurden Hautausschlag
- periphere Ödeme und Anomalien der Serumtransaminase berichtet. Zu den Nebenwirkungen von Seltenheit gehören die Aktivierung von Peptika -Ulkus
- Hämatemese oder Melena
- Blutdyscrasie (umfangreiche Verwendung). Es gab isolierte Berichte über Anaphylaktoidreaktionen. Die nachteiligen Auswirkungen aufgrund von Lidocain betreffen hauptsächlich das ZNS
- sind normalerweise von kurzer Dauer und sind dosisbezogen. Die ZNS-Reaktion kann sich durch Schläfrigkeit
- Schwindel
- Desorientierung
- Verwirrung
- Leuchtkraft usw. manifestieren. Bei 5-10% Patienten können Ungesetzte von Augentropfen auftreten.
Drug Interactions
Diclofenac kann den Blutspiegel von Methotrexat erhöhen. Das Zusammennehmen mit anderen NSAIDs oder Blutverdünnern (wie Warfarin) erhöht das Risiko für Magen- und Darmblutungen. Das Risiko von Nierenproblemen ist höher, wenn es mit Ciclosporin oder Triamteren verwendet wird. Bei Patienten mit schwerwiegenden Hornhautentzündungen kann die Verwendung von Diclofenac -Augentropfen mit Steroid -Augentropfen die Wahrscheinlichkeit von Hornhautschäden erhöhen. Colestyramin und Colestipol niedriger Die Menge an Diclofenac, die Ihr Körper absorbiert. Die Einnahme von Diclofenac nach dem Sucralfat verringert sein Niveau im Blut. Diclofenac -Augentropfen können Acetylcholin- und Carbachol -Augentropfen weniger effektiv machen. Diclofenac könnte auch den Lithium- und Digoxin -Blutspiegel erhöhen.
Der Blutspiegel von Diclofenac kann steigen, wenn sie mit Cimetidin oder Propranolol eingenommen werden. Es besteht eine höhere Wahrscheinlichkeit von Herzproblemen, wenn sie mit Beta-Blockern oder anderen Medikamenten für unregelmäßige Herzschläge eingenommen werden. Diclofenac mit IV -Phenytoin kann unerwünschte Herzeffekte erhöhen. Niedriges Kalium aus Arzneimitteln wie Acetazolamid, Schleifendiuretika oder Thiazide können reduzieren, wie gut Lidocain funktioniert. Wenn Sie lange Zeit Phenytoin oder andere Enzym-induzierende Medikamente verwenden, benötigen Sie möglicherweise höhere Dosen.
Contraindications
Dieses Medikament sollte bei Patienten mit aktivem oder vermutetem Peptika, gastrointestinaler Blutungen oder einer Vorgeschichte von Asthma, Nesselsucht oder schweren Nasenallergien nicht angewendet werden, die von Aspirin oder anderen NSAIDs ausgelöst werden.
Lidocain sollte nicht an Patienten verabreicht werden, von denen bekannt ist, dass sie allergisch gegen Lokalanästhetika vom Typ Amid sind.
Mode of actions
Diclofenac ist ein übliches NSAID (nichtsteroidales entzündungshemmendes Arzneimittel), das zur Phenylessigsäuregruppe gehört. Es hilft, Entzündungen, Schmerzen und Fieber zu reduzieren. Es blockiert die Enzymcykloxygenase, die die Produktion von Substanzen (Prostaglandine) senkt, die Entzündungen verursachen.
Lidocain ist ein Lokalanästhetikum des Amidtyps. Es arbeitet durch Stabilisierung von Nervenzellmembranen und Blockierung von Natriumionen, die für die Reisen von Nerven erforderlich sind. Im Herzen verringert Lidocain die abnormale elektrische Aktivität und automatische Signale im Ventrikel- und Leitungssystem (His-Purkinje-System) und verkürzt die Zeit, für die Herzzellen aktiviert werden.
Dosage & Administration
Erwachsene: Die Dosierung ist im Allgemeinen täglich eine 75 mg Ampulle. In schweren Fällen (z. B. Kolik) kann die tägliche Dosis außergewöhnlich auf zwei Ampullen von 75 mg erhöht werden, die durch ein paar Stunden getrennt sind.
Kinder: Bei jugendlicher chronischer Arthritis 1-3 mg Diclofenac Natrium/kg Körpergewicht täglich in geteilten Dosen.
Ältere Patienten: Die niedrigste wirksame Dosierung wird empfohlen, angemessen mit dem Alter und dem physischen Status oder dem vom Arzt verschriebenen.
Pregnancy & Lactation
Dieses Arzneimittel ist während der Schwangerschaft nicht erlaubt. Verwenden Sie es nicht, wenn Sie schwanger sind. Es kann durch die Haut absorbiert werden und die verursachten Lungen können die Organe Ihres ungeborenen Kindes beschädigen und angeborene Behinderungen verursachen. Strikte wirksame Geburtenkontrolle während der Behandlung und sechs Monate nach der Beendigung dieses Arzneimittels. Wenn Sie schwanger werden, hören Sie auf, dieses Medikament einzunehmen, und besprechen Sie sofort Ihren Arzt.
Es gibt keine spezifischen Informationen darüber, ob dieses Arzneimittel in Muttermilch übergeht oder nicht. In Anbetracht der möglichen Risiken für die Kinder wird das Stillen während der Verwendung dieses Arzneimittels nicht empfohlen und mindestens zwei Wochen nach der letzten Dosis. Wenden Sie sich vor dem Stillen an Ihren Arzt.
Pack Size & Price
10 amps pack Price : ৳100
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