Difenac PLUS IM (Injection)
Manufactured by: Rephco Pharmaceuticals Ltd.
Diclofenac + Lidocaine Hydrochloride Similar medicine
Difenac PLUS IM is indicated for
- Rheumatoid arthritis
- osteoartritis
- ankylosing spondylitis
- nyeri
- asam urat akut
- peradangan
- tendinitis
- keratosis aktinik
- bursitis
Precautions and warnings
Orang dengan riwayat borok lambung, muntah darah, tinja hitam, kolitis ulserativa, asma atau asma masa lalu, penyakit Crohn, masalah pendarahan, atau gangguan darah perlu berhati -hati. Mereka yang memiliki masalah hati, jantung, atau ginjal yang serius, adalah orang tua, atau yang memiliki tekanan darah tinggi saat ini atau masa lalu harus diawasi dengan cermat. Siapa pun yang menggunakan NSAID (seperti Diclofenac Sodium) untuk waktu yang lama harus melakukan pemeriksaan rutin, termasuk tes untuk fungsi ginjal, hati, dan darah. Jika tes hati tetap abnormal, menjadi lebih buruk, atau gejala penyakit hati muncul, natrium diklofenak harus dihentikan.
Side-effects
- Efek samping diklofenak biasanya ringan dan sementara. Umumnya ditoleransi dengan baik. Namun
- pada awal pengobatan
- pasien kadang -kadang dapat mengeluh ketidaknyamanan gastrointestinal
- nyeri epigastria
- ereksi
- mual dan diare
- sakit kepala dan pendarahan suatu saat dapat terjadi. Kadang -kadang ruam kulit
- edema perifer dan kelainan serum transaminase telah dilaporkan. Efek samping yang jarang dilaporkan termasuk aktivasi ulkus peptik
- hematemesis atau melena
- disrasia darah (penggunaan luas). Ada laporan terisolasi dari reaksi anafilaktoid. Efek samping karena lidokain terutama melibatkan SSP
- biasanya berdurasi pendek
- dan terkait dosis. Reaksi SSP dapat dimanifestasikan oleh kantuk
- pusing
- disorientasi
- kebingungan
- lightheadness
- dll. Jika sensasi pembakaran mata tetes mata atau reaksi alergi dapat terjadi pada 5-10% pasien.
Drug Interactions
Diclofenac dapat meningkatkan kadar metotreksat darah. Mengambilnya bersama dengan NSAID atau pengencer darah lainnya (seperti warfarin) meningkatkan risiko lambung dan pendarahan usus. Risiko masalah ginjal lebih tinggi jika digunakan dengan ciclosporin atau triamterene. Pada pasien dengan peradangan kornea yang serius, menggunakan tetes mata diklofenak dengan tetes mata steroid dapat meningkatkan kemungkinan kerusakan kornea. Colestyramine dan colestipol menurunkan jumlah diklofenak yang diserap tubuh Anda. Mengambil diklofenak setelah sukralfat mengurangi kadar darahnya. Tetesan mata diklofenak dapat membuat tetes mata asetilkolin dan carbachol kurang efektif. Diclofenac juga dapat meningkatkan kadar darah lithium dan digoxin.
Tingkat darah diklofenak dapat naik jika diambil dengan cimetidine atau propranolol. Ada kemungkinan lebih tinggi masalah jantung jika diambil dengan beta-blocker atau obat lain untuk detak jantung yang tidak teratur. Diclofenac yang diberikan dengan fenitoin IV dapat meningkatkan efek jantung yang tidak diinginkan. Kalium rendah dari obat seperti acetazolamide, diuretik loop, atau tiazida dapat mengurangi seberapa baik lidokain bekerja. Jika Anda menggunakan fenitoin atau obat-obatan yang menginduksi enzim lainnya untuk waktu yang lama, Anda mungkin memerlukan dosis yang lebih tinggi.
Contraindications
Obat ini tidak boleh digunakan pada pasien yang memiliki ulkus peptik yang aktif atau diduga, perdarahan gastrointestinal, atau riwayat asma, gatal -gatal, atau alergi hidung yang parah yang dipicu oleh aspirin atau NSAID lainnya.
Lidokain tidak boleh diberikan kepada pasien yang diketahui alergi terhadap anestesi lokal tipe amida.
Mode of actions
Diclofenac adalah NSAID yang umum (obat anti-inflamasi non-steroid) yang termasuk dalam gugus asam fenilasetat. Ini membantu mengurangi peradangan, rasa sakit, dan demam. Ini bekerja dengan memblokir enzim siklooksigenase, yang menurunkan produksi zat (prostaglandin) yang menyebabkan peradangan.
Lidocaine adalah anestesi lokal dari tipe amida. Ini bekerja dengan menstabilkan membran sel saraf dan menghalangi ion natrium, yang diperlukan untuk sinyal saraf untuk bepergian. Di jantung, lidokain mengurangi aktivitas listrik yang abnormal dan sinyal otomatis dalam ventrikel dan sistem konduksi (sistem HIS-PURKINJE), dan memperpendek waktu di mana sel jantung diaktifkan.
Dosage & Administration
Dewasa: Dosis umumnya adalah satu ampul setiap hari. Dalam kasus yang parah (mis. Kolik) dosis harian dapat ditingkatkan menjadi dua ampul 75 mg, dipisahkan dengan interval beberapa jam.
Anak-anak: Pada radang sendi kronis remaja, 1-3 mg natrium diklofenak/kg berat badan setiap hari dalam dosis terbagi.
Pasien lanjut usia: Dosis efektif terendah direkomendasikan, sepadan dengan usia dan status fisik atau seperti yang ditentukan oleh dokter.
Pregnancy & Lactation
Obat ini tidak diperbolehkan selama kehamilan. Jangan gunakan itu jika Anda hamil. Ini dapat diserap melalui kulit dan paru -paru yang disebabkan dapat merusak organ anak Anda yang belum lahir dan menyebabkan cacat bawaan. Kontrol kelahiran yang efektif selama perawatan dan selama enam bulan setelah menghentikan obat ini. Jika Anda hamil, berhentilah minum obat ini dan mendiskusikan dokter Anda segera.
Tidak ada informasi spesifik tentang apakah obat ini masuk ke ASI atau tidak. Mempertimbangkan kemungkinan risiko untuk anak -anak, menyusui saat menggunakan obat ini tidak dianjurkan dan setidaknya dua minggu setelah dosis terakhir. Konsultasikan dengan dokter Anda sebelum menyusui.
Pack Size & Price
10 amps pack Price : ৳100
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