Difenac PLUS IM (Injection)
Manufactured by: Rephco Pharmaceuticals Ltd.
Diclofenac + Lidocaine Hydrochloride Similar medicine
Difenac PLUS IM is indicated for
- Artritis reumatoide
- osteoartritis
- espondilitis anquilosante
- dolor
- gota aguda
- inflamación
- tendinitis
- queratosis actínicas
- bursitis
Precautions and warnings
Las personas con antecedentes de úlceras estomacales, vómitos de sangre, heces negras, colitis ulcerosa, asma o asma más allá, enfermedad de Crohn, problemas de sangrado o trastornos sanguíneos deben tener cuidado. Aquellos que tienen problemas graves de hígado, corazón o riñón son ancianos, o que tienen presión arterial alta o pasada, deben ser vigilados de cerca. Cualquier persona que tome AINE (como Diclofenac Sodium) durante mucho tiempo debe tener chequeos regulares, incluidas las pruebas para la función de riñón, hígado y sangre. Si las pruebas hepáticas se mantienen anormales, empeoran o aparecen síntomas de la enfermedad hepática, se debe detener el diclofenaco sodio.
Side-effects
- Los efectos secundarios de diclofenaco suelen ser suaves y transitorios. Generalmente está bien tolerado. Sin embargo
- al comienzo del tratamiento
- los pacientes a veces pueden quejarse de molestias gastrointestinales
- dolor de epigastria
- eructos
- náuseas y diarrea
- dolor de cabeza y sangrado en algún momento. Ocasionalmente
- se han informado erupción cutánea
- edema periférico y anormalidades de la transaminasa sérica. Los efectos secundarios muy raramente informados incluyen la activación de úlceras pépticas
- hematemesis o melena
- discrasia sanguínea (uso extenso). Ha habido informes aislados de reacciones anafilactoides. Los efectos adversos debido a la lidocaína involucran principalmente el SNC
- generalmente son de corta duración y están relacionadas con la dosis. La reacción del SNC puede manifestarse mediante somnolencia
- mareos
- desorientación
- confusión
- prostitución
- etc. En caso de gotas para los ojos
- la sensación de quema ocular o la reacción alérgica pueden ocurrir en 5-10% de pacientes.
Drug Interactions
Diclofenaco puede elevar los niveles sanguíneos de metotrexato. Tomarlo junto con otros AINE o anticoagulantes (como la warfarina) aumenta el riesgo de sangrado del estómago y intestino. El riesgo de problemas renales es mayor si se usa con ciclosporina o triamtereno. En pacientes con inflamación corneal existente, el uso de gotas oculares de diclofenaco con gotas de los ojos esteroides puede aumentar las posibilidades de daño corneal. La colestiramina y el colestipol reducen la cantidad de diclofenaco que su cuerpo absorbe. Tomar diclofenaco después de la sucalfato disminuye su nivel en la sangre. Las gotas para los ojos del diclofenaco pueden hacer que las gotas oculares de acetilcolina y carbacolos sean menos efectivas. El diclofenaco también podría elevar los niveles de litio y digoxina en sangre.
Los niveles sanguíneos de diclofenaco pueden aumentar si se toman con cimetidina o propranolol. Hay una mayor probabilidad de problemas cardíacos si se toman con betabloqueantes u otras drogas para latidos irregulares. El diclofenaco administrado con fenitoína IV puede aumentar los efectos cardíacos no deseados. El bajo potasio de las drogas como la acetazolamida, los diuréticos de bucle o las tiazidas pueden reducir lo bien que funciona la lidocaína. Si usa fenitoína u otros medicamentos inductores de enzimas durante mucho tiempo, es posible que necesite dosis más altas.
Contraindications
Este medicamento no debe usarse en pacientes que tienen una úlcera péptica activa o sospechosa, sangrado gastrointestinal o antecedentes de asma, colmenas o alergias nasales graves desencadenadas por aspirina u otros AINE.
No se debe administrar lidocaína a pacientes que se sabe que son alérgicos a los anestésicos locales de tipo amida.
Mode of actions
El diclofenaco es un AINE común (fármaco antiinflamatorio no esteroideo) que pertenece al grupo de ácido fenilacético. Ayuda a reducir la inflamación, el dolor y la fiebre. Funciona bloqueando la enzima ciclooxigenasa, lo que reduce la producción de sustancias (prostaglandinas) que causan inflamación.
La lidocaína es un anestésico local del tipo de amida. Funciona estabilizando las membranas de las células nerviosas y el bloqueo de los iones de sodio, que son necesarios para que las señales nerviosas viajen. En el corazón, la lidocaína disminuye la actividad eléctrica anormal y las señales automáticas en los ventrículos y el sistema de conducción (sistema His-Purkinje), y acorta el tiempo en que se activan las células cardíacas.
Dosage & Administration
Adultos: la dosis es generalmente una ampolla de 75 mg diariamente. En casos severos (por ejemplo, cólico), la dosis diaria se puede aumentar excepcionalmente a dos ampolas de 75 mg, separadas por un intervalo de unas pocas horas.
Niños: en artritis crónica juvenil, 1-3 mg de diclofenaco sodio/kg de peso corporal diariamente en dosis divididas.
Pacientes de edad avanzada: se recomienda la dosis efectiva más baja, acorde con la edad y el estado físico o según lo prescrito por el médico.
Pregnancy & Lactation
Este medicamento no está permitido durante el embarazo. No lo use si está embarazada. Se puede absorber a través de la piel y los pulmones causados pueden dañar los órganos de su hijo no nacido y causar discapacidades congénitas. Control de natalidad estricto efectivo durante el tratamiento y durante seis meses después de detener este medicamento. Si queda embarazada, deje de tomar este medicamento y discuta a su médico de inmediato.
No hay información específica sobre si este medicamento pasa a la leche materna o no. Teniendo en cuenta los posibles riesgos para los niños, no se recomienda la lactancia al usar este medicamento y al menos dos semanas después de la última dosis. Consulte a su médico antes de amamantar.
Pack Size & Price
10 amps pack Price : ৳100
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