Difenac PLUS IM (Injection)
Manufactured by: Rephco Pharmaceuticals Ltd.
Diclofenac + Lidocaine Hydrochloride Similar medicine
Difenac PLUS IM is indicated for
- Artrite reumatóide
- osteoartrite
- espondilite anquilosante
- dor
- gota aguda
- inflamação
- tendinite
- queratoses actínicas
- bursite
Precautions and warnings
Pessoas com histórico de úlceras estomacais, sangue vomitando, fezes pretas, colite ulcerosa, asma ou asma passada, doença de Crohn, problemas de sangramento ou distúrbios do sangue precisam ter cuidado. Aqueles que têm problemas graves, coração ou renais, são idosos ou que têm pressão alta ou passada na alta deve ser observada de perto. Qualquer pessoa que toma AINEs (como diclofenac sódico) por um longo tempo deve ter exames regulares, incluindo testes para rim, fígado e função de sangue. Se os testes hepáticos permanecerem anormais, piorem ou os sintomas da doença hepática aparecerem, o diclofenaco de sódio deve ser interrompido.
Side-effects
- Os efeitos colaterais do diclofenaco são geralmente leves e transitórios. Geralmente é bem tolerado. No início do tratamento
- no entanto
- os pacientes às vezes podem reclamar de desconforto gastrointestinal
- dor de epigástria
- eructação
- náusea e diarréia
- dor de cabeça e sangramento em algum momento. Ocasionalmente
- a erupção cutânea
- edema periférico e anormalidades da transaminase sérica foram relatadas. Muito raramente relatados efeitos colaterais incluem a ativação da úlcera péptica
- hematemesis ou melena
- discrasia sanguínea (uso extensivo). Houve relatos isolados de reações de anafilactóides. Os efeitos adversos devido à lidocaína envolvem principalmente o SNC
- geralmente são de curta duração e estão relacionados à dose. A reação do SNC pode se manifestar por sonolência
- tontura
- desorientação
- confusão
- folha de faróis
- etc.
- no caso dos colírios sensação de queimação ocular ou reação alérgica em 5 a 10% dos pacientes.
Drug Interactions
O diclofenaco pode aumentar os níveis sanguíneos de metotrexato. Tomar -se junto com outros AINEs ou diluentes de sangue (como a varfarina) aumenta o risco de estômago e sangramento intestinal. O risco de problemas renais é maior se usado com ciclosporina ou triamtereno. Em pacientes com inflamação grave existente na córnea, o colírio diclofenaco com colírios esteróides pode aumentar a chance de danos à córnea. Colestiramina e Colestipol reduzem a quantidade de diclofenaco que seu corpo absorve. Tomar diclofenac após o sucralfato diminui seu nível no sangue. Os colírios diclofenac podem tornar os colírios de acetilcolina e carbachol menos eficazes. O diclofenac também pode aumentar os níveis sanguíneos de lítio e digoxina.
Os níveis sanguíneos de diclofenaco podem subir se tomados com cimetidina ou propranolol. Há uma chance maior de problemas cardíacos se tomados com betabloqueadores ou outras drogas para batimentos cardíacos irregulares. O diclofenaco dado com fenitoína IV pode aumentar os efeitos cardíacos indesejados. Potássio baixo de drogas como acetazolamida, diuréticos de loop ou tiazidas podem reduzir o desempenho da lidocaína. Se você usar fenitoína ou outros medicamentos indutores de enzima por um longo tempo, poderá precisar de doses mais altas.
Contraindications
Este medicamento não deve ser usado em pacientes que tenham uma úlcera péptica ativa ou suspeita, sangramento gastrointestinal ou histórico de asma, colméias ou alergias nasais graves desencadeadas por aspirina ou outros AINEs.
A lidocaína não deve ser dada a pacientes conhecidos por serem alérgicos aos anestésicos locais do tipo amida.
Mode of actions
O diclofenac é um AINE comum (medicamento anti-inflamatório não esteróide) que pertence ao grupo de ácido fenilacético. Ajuda a reduzir a inflamação, a dor e a febre. Funciona bloqueando a enzima ciclooxigenase, que reduz a produção de substâncias (prostaglandinas) que causam inflamação.
A lidocaína é um anestésico local do tipo amida. Funciona estabilizando as membranas das células nervosas e bloqueando íons de sódio, necessários para os sinais nervosos viajarem. No coração, a lidocaína diminui a atividade elétrica anormal e os sinais automáticos no sistema de ventrículos e condução (sistema His-Purkinje) e diminui o tempo para o qual as células cardíacas são ativadas.
Dosage & Administration
Adultos: A dosagem é geralmente uma ampola de 75 mg diariamente. Em casos graves (por exemplo, cólica), a dose diária pode ser excepcionalmente aumentada para duas ampolas de 75 mg, separadas por um intervalo de algumas horas.
Crianças: em artrite crônica juvenil, 1-3 mg de diclofenaco sódico/kg de peso corporal diariamente em doses divididas.
Pacientes idosos: a menor dosagem efetiva é recomendada, proporcional à idade e status físico ou conforme prescrito pelo médico.
Pregnancy & Lactation
Este medicamento não é permitido durante a gravidez. Não use -o se estiver grávida. Pode ser absorvido pela pele e os pulmões causados podem danificar os órgãos do seu filho ainda não nascido e causar deficiências congênitas. Controle eficaz rigoroso da natalidade durante o tratamento e por seis meses depois de interromper este medicamento. Se você engravidar, pare de tomar este medicamento e discuta seu médico imediatamente.
Não há informações específicas sobre se este medicamento passa para o leite materno ou não. Considerando os possíveis riscos para as crianças, a amamentação ao usar este medicamento não é recomendada e pelo menos duas semanas após a última dose. Consulte seu médico antes de amamentar.
Pack Size & Price
10 amps pack Price : ৳100
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