Difenac PLUS IM (Injection)
Manufactured by: Rephco Pharmaceuticals Ltd.
Diclofenac + Lidocaine Hydrochloride Similar medicine
Difenac PLUS IM is indicated for
- Polyarthrite rhumatoïde
- arthrose
- spondylite ankylosante
- douleur
- goutte aiguë
- inflammation
- tendinite
- kératoses actiniques
- bursite
Precautions and warnings
Les personnes ayant des antécédents d'ulcères d'estomac, de sang de vomissements, de selles noires, de colite ulcéreuse, d'asthme ou d'asthme passé, de maladie de Crohn, de problèmes de saignement ou de troubles sanguins doivent être prudents. Ceux qui ont de graves problèmes de foie, de cœur ou de rein sont des personnes âgées ou qui ont une pression artérielle actuelle ou passée devraient être surveillés de près. Quiconque prend des AINS (comme le diclofénac de sodium) pendant longtemps devrait avoir des contrôles réguliers, y compris des tests de fonction rénale, hépatique et sanguin. Si les tests hépatiques restent anormaux, aggravent ou que les symptômes de la maladie du foie apparaissent, le diclofénac sodium doit être arrêté.
Side-effects
- Les effets secondaires du diclofénac sont généralement légers et transitoires. Il est généralement bien toléré. Au début du traitement
- cependant
- les patients peuvent parfois se plaindre de l'inconfort gastro-intestinal
- de la douleur à l'épigastrie
- de l'éructation
- des nausées et de la diarrhée
- des maux de tête et des saignements peuvent parfois se produire. Parfois
- une éruption cutanée
- un œdème périphérique et des anomalies de la transaminase sérique ont été rapportés. Des effets secondaires rarement signalés incluent l'activation de l'ulcère gastro-duodénal
- de l'hématemèse ou de la mélena
- une dyscrasie sanguine (utilisation étendue). Il y a eu des rapports isolés de réactions anaphylactoïdes. Les effets indésirables dus à la lidocaïne impliquent principalement le SNC
- sont généralement de courte durée et sont liés à la dose. La réaction du SNC peut se manifester par la somnolence
- les étourdissements
- la désorientation
- la confusion
- la légèreté
- etc. En cas de sensation de combustion oculaire ou de réaction allergique oculaire peut se produire chez 5 à 10% de patients.
Drug Interactions
Le diclofénac peut augmenter les taux sanguins de méthotrexate. La prise avec d'autres AINS ou anticoagulants (comme la warfarine) augmente le risque de saignement de l'estomac et de l'intestin. Le risque de problèmes rénaux est plus élevé s'il est utilisé avec la ciclosporine ou le triamterène. Chez les patients présentant une inflammation cornéenne grave existante, l'utilisation de gouttes oculaires de diclofénac avec des gouttes oculaires stéroïdes peut augmenter les risques de dommages cornéens. Colestyramine et Colestipol baisser la quantité de diclofénac que votre corps absorbe. La prise de diclofénac après le sacralfate diminue son niveau dans le sang. Les gouttes oculaires du diclofénac peuvent rendre l'acétylcholine et les gouttes oculaires de carbachol moins efficaces. Le diclofénac pourrait également augmenter les taux de lithium et de digoxine.
Les taux sanguins de diclofénac peuvent augmenter s'ils sont pris avec de la cimétidine ou du propranolol. Il y a un risque plus élevé de problèmes cardiaques s'ils sont pris avec des bêta-bloquants ou d'autres médicaments pour des battements cardiaques irréguliers. Le diclofénac donné avec la phénytoïne IV peut augmenter les effets cardiaques indésirables. Le faible potassium à partir de médicaments comme l'acétazolamide, les diurétiques en boucle ou les thiazides peut réduire le fonctionnement de la lidocaïne. Si vous utilisez une phénytoïne ou d'autres médicaments induisant les enzymes pendant longtemps, vous pourriez avoir besoin de doses plus élevées.
Contraindications
Ce médicament ne doit pas être utilisé chez les patients qui ont un ulcère gastro-du bienfaisance actif ou suspecté, des saignements gastro-intestinaux ou des antécédents d'asthme, des ruches ou des allergies nasales sévères déclenchées par l'aspirine ou d'autres AINS.
La lidocaïne ne doit pas être donnée aux patients connus pour être allergiques aux anesthésiques locaux de type amide.
Mode of actions
Le diclofénac est un AINS commun (médicament anti-inflammatoire non stéroïdal) qui appartient au groupe d'acide phénylacétique. Il aide à réduire l'inflammation, la douleur et la fièvre. Il fonctionne en bloquant l'enzyme cyclooxygénase, qui réduit la production de substances (prostaglandines) qui provoquent une inflammation.
La lidocaïne est une anesthésie locale du type amide. Il fonctionne en stabilisant les membranes des cellules nerveuses et en bloquant les ions sodium, qui sont nécessaires pour que les signaux nerveux se déplacent. Dans le cœur, la lidocaïne diminue une activité électrique anormale et des signaux automatiques dans le système de ventricules et de conduction (système de purkinje) et raccourcit le temps pour lequel les cellules cardiaques sont activées.
Dosage & Administration
Adultes: Le dosage est généralement un ampoule de 75 mg par jour. Dans les cas graves (par exemple, les coliques), la dose quotidienne peut être exceptionnellement augmentée à deux ampoules de 75 mg, séparées par un intervalle de quelques heures.
Enfants: Dans l'arthrite chronique juvénile, 1 à 3 mg de diclofénac sodium / kg de poids corporel par jour en doses divisées.
Patients âgés: la dose efficace la plus faible est recommandée, proportionnée à l'âge et à l'état physique ou comme prescrit par le médecin.
Pregnancy & Lactation
Ce médicament n'est pas autorisé pendant la grossesse. Ne l'utilisez pas si vous êtes enceinte. Il peut être absorbé par la peau et les poumons causés à endommager les organes de votre enfant à naître et provoquer des handicaps congénitaux. Un contrôle des naissances efficace strict pendant le traitement et pendant six mois après l'arrêt de ce médicament. Si vous tombez enceinte, arrêtez de prendre ce médicament et discutez immédiatement de votre médecin.
Il n'y a aucune information spécifique sur le fait que ce médicament passe dans le lait maternel ou non. Compte tenu des risques possibles pour les enfants, l'allaitement maternel lors de l'utilisation de ce médicament n'est pas recommandé et au moins deux semaines après la dernière dose. Consultez votre médecin avant l'allaitement.
Pack Size & Price
10 amps pack Price : ৳100
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