Permival (Tablet)
Manufactured by: Opsonin Pharma Limited
Fluphenazine Hydrochloride + Nortriptyline Similar medicine
Permival is indicated for
- Headache
- Depression
- Anxiety
- Emotional disturbance
- Tension
- Fatigue
- Sleep disorder
- Bodyache
- Gastric problems
Precautions and warnings
Patients with glaucoma, enlarged prostate, heart failure, or recent heart attack should use this medication with caution. The drug can make you feel less alert and may affect your ability to drive or use machines safely.
Fluphenazine hydrochloride should be used carefully in people who have had allergic reactions—such as jaundice or skin rashes—to similar drugs (phenothiazines), because they might react to this medicine too.
Patients with mental health conditions taking high doses of phenothiazines and needing surgery should be closely watched for low blood pressure. Additionally, doctors may need to lower the dose of anesthesia or other drugs that slow down the nervous system.
Finally, fluphenazine may increase the effects of atropine in some patients, which could lead to stronger anticholinergic side effects.
Side-effects
- Dryness of mouth
- drowsiness
- constipation
- tachycardia
- nasal congestion
- blurred vision
- excitement.
Drug Interactions
This medication can weaken the blood pressure-lowering effects of drugs like guanethidine, methyldopa, and clonidine. It can also increase the risk of lithium toxicity. Taking it with antacids may make it less effective. Using it with medicines that prolong the QT interval can raise the chance of heart rhythm problems. When combined with diuretics, there is a risk of problems with your body’s electrolytes.
Dangerously, when taken with alcohol, barbiturates, sleeping pills, sedatives, opiates, or antihistamines, it can cause excessive drowsiness and depress the central nervous system.
Contraindications
Fluphenazine hydrochloride should not be used in patients who have suspected or confirmed damage to the deeper parts of the brain, patients taking high doses of sleeping medications, or those who are in a coma or are severely depressed. It is also not suitable for people with blood disorders or liver problems. Anyone who is allergic to fluphenazine, or who has had a reaction to other similar medications (phenothiazines), should not take this drug.
Mode of actions
Fluphenazine works by blocking certain dopamine receptors in the brain, which helps lower aggression and can make hallucinations and delusions go away. It also reduces the release of some hormones from the brain.
Nortriptyline is a type of antidepressant, related to amitriptyline, that increases the amount of serotonin and norepinephrine in the brain by preventing their reabsorption. This helps improve mood.
Dosage & Administration
Adult: 1 tablet 2 to 3 times daily.
Child: Not recommended.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
200's pack Price : ৳131.89
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