Topiclo-S (Ointment)
Manufactured by: Eskayef Bangladesh Ltd.
Clobetasol Propionate 0.05% + Salicylic Acid 3% Similar medicine
Topiclo-S is indicated for
- Psoriasis
- brûlures
- acné vulgaire
- eczéma
- dyskératose
- ichtyose
- verrues
- hyperkératose
- maïs
- callosités
- séborrhée
- maladie cutanée squameuse
- perte de cheveux
- transpiration des pieds
- dermatite
Precautions and warnings
N'utilisez pas ce produit en grande quantité ou sur de grandes zones du corps pendant une période prolongée. Si vous avez une mauvaise circulation sanguine ou du diabète, soyez très prudent. Ne l'appliquez pas sur une peau éraflée, à l'intérieur de la bouche, des yeux, des muqueuses ou des zones génitales et anales.
Side-effects
- L'utilisation prolongée d'une grande quantité de propionate de clobétasol peut conduire à des niveaux systémiques suffisants pour produire une suppression surrénalienne
- le syndrome de Cushing
- le diabète et l'hypertension. Atrophie cutanée et épidermique
- en particulier sur le visage
- purpura stéroïdien.
Drug Interactions
Propionate de clobétasol : la prise de ce médicament avec des inhibiteurs du CYP3A4 (comme le ritonavir ou l'itraconazole) peut augmenter la quantité de clobétasol dans votre corps.
Mode of actions
**Les corticostéroïdes** réduisent l'inflammation de plusieurs manières. Ils maintiennent certaines membranes de cellules immunitaires stables afin d'éviter la libération d'enzymes nocives, empêchent les macrophages de se rassembler sur les sites enflammés et rendent plus difficile l'adhésion des globules blancs aux parois des vaisseaux sanguins. Ils diminuent également la facilité avec laquelle le liquide s’échappe des vaisseaux sanguins, ce qui aide à prévenir l’enflure, et diminuent les niveaux de protéines impliquées dans la réponse immunitaire. De plus, les corticostéroïdes bloquent les effets de l’histamine et réduisent la libération de kinines, toutes deux impliquées dans l’inflammation. Ils ralentissent également l’activité des cellules (fibroblastes) qui produisent du collagène et du tissu cicatriciel.
**L'acide salicylique** agit principalement en décomposant et en adoucissant la couche externe de la peau (la couche cornée) lorsqu'il est appliqué sur la peau. Cela augmente l’humidité de la peau, ce qui fait gonfler, ramollir et finalement perdre cette couche. En grande quantité, l’acide salicylique peut brûler la peau. En plus de cela, il possède de légères propriétés antibactériennes et antifongiques.
Dosage & Administration
Adulte : acné topique ; Conditions cutanées hyperkératosiques et squameuses Comme préparation à 2-6% : Appliquer >3 fois/jour. Verrues et callosités Comme préparation à 60 % : Appliquer comme indiqué.
Pregnancy & Lactation
Bien que des études sur la reproduction animale aient montré un effet indésirable sur le fœtus et qu'il n'existe pas d'études adéquates et bien contrôlées chez la femme enceinte, ce médicament peut être utilisé pendant la grossesse juste lorsque cela est absolument nécessaire, malgré les risques potentiels.
Les mères d'un nouveau-né qui ont utilisé ce médicament au cours des 3 derniers mois de leur grossesse peuvent rarement créer des symptômes tels que somnolence, raideur ou tremblements musculaires, troubles de l'alimentation ou de la respiration, pleurs constants. Si vous remarquez l'un de ces symptômes chez votre bébé, en particulier au cours de son premier mois, informez-en immédiatement le médecin.
Ce médicament passe dans le lait maternel. Parlez-en à votre médecin avant d'allaiter.
Pack Size & Price
10gm tube Price : ৳70
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