Anafranil 25mg (Tablet)
Manufactured by: Novartis (Bangladesh) Ltd.
Clomipramine Hydrochloride Similar medicine
Anafranil is indicated for
- Depression
- Panic disorder
- Obsessive compulsive disorder
- Cataplexy
- Narcolepsy
- Phobias
- Premature ejaculation
- Enuresis
- Trichotillomania
Precautions and warnings
People with the following conditions should be cautious: heart problems, narrow-angle glaucoma, difficulty urinating, a history of epilepsy, kidney or liver issues, undergoing electric shock therapy, low blood pressure, overactive thyroid or taking thyroid medicine, suicidal thoughts, those about to have surgery, pregnant or breastfeeding women, those doing work that needs mental focus, and older adults. Do not suddenly stop taking this medication.
Side-effects
- Dryness of mouth; disturbances in micturition; drowsiness
- increased sweating; sexual dysfunction; confusion
- paraesthesia
- ataxia
- tremors; extrapyramidal symptoms; tinnitus
- dizziness
- fatigue
- headache; wt gain esp in women; gynaecomastia
- galactorrhoea. Potentially Fatal: Death
- rare (except in patients with preexisting significant heart block
- patients on MAOI therapy). Induction of mania in individuals with underlying manic-depressive illness or worsening of psychoses in already psychotic individuals.
Drug Interactions
Barbiturates make the body break down tricyclic antidepressants faster, while drugs like cimetidine, guanethidine, haloperidol, and phenothiazines slow down their breakdown. Alcohol’s effects on the brain are stronger if used together.
**Serious Warning:** If switching from MAOIs to clomipramine, wait at least 3 weeks after stopping MAOIs. Using adrenaline or noradrenaline with tricyclics can raise the risk of high blood pressure and abnormal heart rhythms.
Contraindications
Do not use this medicine if you are allergic to it. Avoid using it at the same time as MAOIs (a type of medication). It should not be used during recovery after a heart attack, in people with heart block or other irregular heartbeats, during episodes of mania, or in children.
Mode of actions
Clomipramine strongly blocks the re-uptake of serotonin in the brain. It also significantly blocks cholinergic and alpha-1 receptors, while only weakly affecting dopamine receptors. This medicine has antidepressant, calming (sedative), and anticholinergic effects.
Dosage & Administration
Adult: PO Adjunct in cataplexy associated w/ narcolepsy Initial: 10 mg/day, up to 75 mg/day.
Obsessive-compulsive disorder; Panic disorder; Phobias Initial: 25 mg/day, gradually increase up to 100-150 mg/day if needed. Max: 250 mg/day.
Depression Initial: 10 mg/day, up to 30-150 mg/day if needed. >250 mg/day may be needed in severe cases.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
50's pack Price : ৳276.5
Similar medicine
Manufactured by: Orion Pharma Ltd.
Manufactured by: Novartis (Bangladesh) Ltd.
Manufactured by: Sun Pharmaceutical (Bangladesh) Ltd.
Click here to see more similar medicines
There are few similar medicines of Anafranil are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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